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International Journal of Pharmaceutical InvestigationNOW IN
Article

Effectiveness and Safety of Levonorgestrel Intrauterine Device in Abnormal Uterine Bleeding, Adenomyosis and Perimenopausal Bleeding Patients

Aayushi Jaiswal1, Mudumba Srivarshini1, Patlolla Akshitha Reddy1, Tripura Sundari2, Sirisha Sunkavalli2, Ramya Vandanasetti2, Shaheen Begum3, Arifa Begum SK1★★ Corresponding author

  1. 1Department of Pharmacy, Bharat Institute of Technology, Mangalpally, Ibrahimpatnam, Hyderabad, Telangana, INDIA.
  2. 2Department of Obstetrics and Gynaecology, Krishna Institute of Medical Sciences, Secunderabad, Telangana, INDIA.
  3. 3Department of Pharmacy, Institute of Pharmaceutical Technology, SPMVV, Tirupati, Andhra Pradesh, INDIA.

CORRESPONDENCE

Arifa Begum SK

Department of Pharmacy, Bharat Institute of Technology, Mangalpally, Ibrahimpatnam, Hyderabad, Telangana, INDIA.

arifabegum@bitpharmacy.org

Received: 27-07-2023; Revised: 07-09-2023; Accepted: 23-10-2023.

Volume 14, Issue 1 · pp. 186–190 · PUBLISHED · DOI: 10.5530/ijpi.14.1.24

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ABSTRACT

Background:The Levonorgestrel-releasing intrauterine system was inserted in patients with conditions like Abnormal Uterine Bleeding (AUB), adenomyosis and Perimenopausal Bleeding (PMB). This study aimed to find the effectiveness and safety of the intrauterine device in AUB, adenomyosis and PMB. Materials and Methods:This observational study enrolled 100 patients with AUB, adenomyosis and PMB who had levonorgestrel IUD inserted for treatment between the years 2015 to 2022. The data has been collected from the Department of Obstetrics and Gynecology at Krishna Institute of Medical Sciences, Secunderabad and analyzed based on the Institutional outcome scoring form. The post-insertion responses, expulsion rates and clinical outcomes towards IUD were observed in patients after insertion. Results: The analysis of post-insertion responses showed a significant statistical P value of 0.001 which implies the effectiveness of IUD. This study resulted in a 90% positive clinical outcome which implies the safety of levonorgestrel IUD. The expulsion rate was also very low that was 5 out of 100 patients had the device expelled.Conclusion: The levonorgestrel IUD showed significant positive clinical outcomes in patients with AUB, Adenomyosis and PMB with low expulsion rates and can be considered a good alternative for conservative management of AUB, Adenomyosis, and perimenopausal bleeding.

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    Jaiswal, A., Srivarshini, M., Reddy, P. A., Sundari, T., Sunkavalli, S., Vandanasetti, R., Begum, S., & SK, A. B. (). Effectiveness and Safety of Levonorgestrel Intrauterine Device in Abnormal Uterine Bleeding, Adenomyosis and Perimenopausal Bleeding Patients. International Journal of Pharmaceutical Investigation, 14(1), 186–190. https://doi.org/10.5530/ijpi.14.1.24