jrnls.org logo
Submit

BROWSE ALL JOURNALS

SEE ALL 19 JOURNALS
International Journal of Pharmaceutical InvestigationNOW IN
Article

Development and Characterization of Rivastigmine Hydrogen Tartrate Elementary Osmotic Tablets

Ayesha Naz1★, CVS Subrahmanyam2, Shyam Sunder Rachamalla1★ Corresponding author

  1. 1Department of Pharmacy, UCT, Osmania University, Hyderabad, Telangana, INDIA.
  2. 2Department of Pharmaceutics, Gokaraju Rangaraju College of Pharmacy, Osmania University, Hyderabad, Telangana, INDIA.

CORRESPONDENCE

Ayesha Naz

Department of Pharmacy, UCT, Osmania University, Hyderabad, Telangana, INDIA.

ayesha.naz06@gmail.com

Received: 27-09-2023; Revised: 07-10-2023; Accepted: 03-12-2023.

Volume 14, Issue 1 · pp. 239–249 · PUBLISHED · DOI: 10.5530/ijpi.14.1.30

View on IJPI original site ↗

ABSTRACT

Background:The present study aims to develop an Elementary Osmotic tablet (EOP) of Rivastigmine Hydrogen Tartrate (RHT). EOP consists of a core tablet suitably coated with a polymeric solution, and an orifice drilled on one side of the tablet. Materials and Methods: The influence of core variables, including sodium chloride (osmogen) concentration and Polyvinyl Pyrrolidine K30 (PVP K30) concentration, have been investigated and optimized by factorial design. The effect of membrane (coating) variables, including polyethylene glycol 400 (PEG 400) amount and percent coating weight gain have been studied. The rivastigmine release of the optimized system has been investigated in various dissolution media, at different stirring rates, at variable pH, and variable osmotic pressure. Results: It was observed that PEG 400 incorporated in the coating membrane improved drug release. The sodium chloride had a profoundly positive influence, and PVP K30 had a negative influence on the rivastigmine release. The finding reveals that the core tablet containing sodium chloride (50 mg) and PVP K30 (2.5 mg) coated with the solution containing 20% PEG 400 and 5% weight gain was optimized. Conclusion:The developed EOP provides the RHT release for up to 24 hr with improved bioavailability. The results instigated a controlled release of rivastigmine.

KEYWORDS

Open in new tab

REFERENCES

As published

Showing references and in-text citations exactly as published.

    Cite this article

    SELECT FORMAT

    Naz, A., Subrahmanyam, C., & Rachamalla, S. S. (). Development and Characterization of Rivastigmine Hydrogen Tartrate Elementary Osmotic Tablets. International Journal of Pharmaceutical Investigation, 14(1), 239–249. https://doi.org/10.5530/ijpi.14.1.30