Evaluation of Momordica cymbalaria Fenzl (MC) In Healing Burn Wounds

ABSTRACT

Background:The study aimed to evaluate the potential of Momordica cymbalaria Fenzl (MC) in healing burn wounds. Partial-thickness scald wounds were induced on SD rats by pouring hot molten wax at 800°C on the dorsal area of the rat. Rats were placed into five groups (n=6). 1st group served as the wound control (Untreated) group. The rest of the 4 groups received SSC (1% w/w), 5% extract of MC, Scaffold, and 5%, Saponin of MC topically respectively twice daily for 14 days. Wound contraction and period of epithelization were checked on days 1,9 and 14. On the 9th day, the granulation tissue was isolated and estimated for hydroxyproline content and antioxidant enzymes. A part of the granulation tissue was processed for histopathology studies. Results: 5% extract and Saponin of Momordica cymbalaria Fenzl promoted wound contraction and decreased the period of epithelization when compared with control but lesser than the SSC-treated group. It also enhanced collagen synthesis and wound stability, as demonstrated by an elevation in hydroxyproline content. The histological examinations also affirmed the healing potential of the drug, which showed a full form of epidermis layer, less inflammatory cells, more no. of collagen fibers, and blood vessels lesser than the SSC-treated group and scaffold. Endogenous enzymatic and non-enzymatic antioxidant levels increased significantly in the Momordica cymbalaria Fenzl -treated groups, while lipid peroxide levels decreased. Conclusion: By 5% extract, Momordica cymbalaria saponin, and scaffold have great healing capacity in burn wounds and have a beneficial influence on the various stages of wound restoration.

KEYWORDS

• Burn wound
• Saponins
• Scaffold
• Hydroxyproline
• Antioxidant activity

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• DOI10.5530/ijpi.13.4.115Copy