Volume 3, Issue 1

Steffy B Manjila, Jomon N Baby, Elambilan N Bijin, Icey Constantine, Kannissery Pramod, Janardhanan Valsalakumari

pp. 1–7 · 2013

Gene therapy is an emerging field in medical and pharmaceutical sciences because of its potential in treating chronic diseases like cancer, viral infections, myocardial infarctions, and genetic disorders. Application of …

Amit Goel, Sanjula Baboota, Jasjeet K Sahni, Javed Ali

pp. 8–14 · DOI: 10.4103/2230-973X.108959 · 2013

Lung cancer is the most malignant cancer today. The treatment of lung cancer continues to be a challenge for oncologists. The direct delivery of chemotherapeutic agents to the lungs could represent a novel therapeutic ap…

Amit Mukharya, Paresh U Patel, Dinesh Shenoy, Shivang Chaudhary

pp. 15–28 · DOI: 10.4103/2230-973X.108960 · 2013

Introduction: Lacidipine (LCDP) is a very low soluble and highly biovariable calcium channel blocker used in the treatment of hypertension. To increase its apparent solubility and to reduce its biovariability, solid disp…

Kevin Garala, Parth Joshi, Malay Shah, A Ramkishan, Jaydeep Patel

pp. 29–41 · DOI: 10.4103/2230-973X.108961 · 2013

Background: The present study was aimed to develop and optimize in situ gel for the treatment of periodontal disease. Materials and Methods: Temperature‑sensitive in situ gel containing 0.1% w/v Chlorhexidine hydrochlori…

Raj Kaur Malik, Prashant Malik, Neha Gulati, Upendra Nagaich

pp. 42–46 · DOI: 10.4103/2230-973X.108962 · 2013

Background: Mucoadhesive beads were fabricated and evaluated for controlled release of an antiemetic drug ‘Ondansetron Hydrochloride’. Ondansetron hydrochloride is a serotonin 5‑HT3 receptor antagonist mainly used for th…

Mohasin Lodhi, Akhilesh Dubey, Reema Narayan, Prabhakara Prabhu, Sneh Priya

pp. 47–53 · DOI: 10.4103/2230-973X.108963 · 2013

Background: Ivabradine hydrochloride is an anti‑anginal drug with a biological half‑life of about 2 h, and repeated daily administration is needed to maintain effective plasma level. Present investigation of buccal films…

Abdul Wadood Khan, Sabna Kotta, Sudha Rana, Shahid Husain Ansari, Rakesh Kumar Sharma, Javed Ali

pp. 54–59 · DOI: 10.4103/2230-973X.108964 · 2013

Background:Increased use of the radioactive materials in the field of research, medical, nuclear power plant, and industry has increased the risk of accidental exposure. Intentional use of the radioisotopes by terrorist …

Vikas Mathur, Kalpana Nagpal, Shailendra Kumar Singh, Dina Nath Mishra

pp. 60–65 · DOI: 10.4103/2230-973X.108965 · 2013

Introduction: Verapamil hydrochloride (VH) is a calcium channel blocking agent used in the treatment of hypertension, cardiac arrhythmia and angina pectoris. The short half‑life and high frequency of administration of VH…