Article · Volume 4, Issue 1 · pp. 15–18

Polyethylene glycolated PAMAM dendrimers-Efavirenz conjugates

Suneela Pyreddy¹, Pandurangan Dinesh Kumar¹, Palanirajan Vijayaraj Kumar²

¹Department of Pharmaceutics, Hindu College of Pharmacy, Acharya Nagarjuna University, Guntur, Andhra Pradesh, INDIA.
²School of Pharmacy, University College Sadaya International University, JalanMenara Gading, Kuala Lumpur, MALAYSIA.

Abstract

Aim: The preparation of novel PEGylated PAMAM (poly-amidoamine) dendrimers for delivery of anti-HIV drug Efavirenz is reported.Method and Materials: About 5.0 G PAMAM dendrimers are prepared by ethylene diamine core via Michael addition by divergent method. PEGylation is done by polyethylene glycol 600 using epichlorhydrin as linker. PEGylated 5.0 G PAMAM dendrimers loaded with Efavirenz (EFV) are evaluated for FTIR, DSC, SEM, drug release, and stability studies. Results and Conclusion:From the results it is proved that this method is less time consuming, inexpensive, and reproducible. Drug-release studies indicate, PEGylated 5.0 G PAMAM-EFV dendrimers have shown prolonged drugrelease property.

Keywords: Dendrimers; efavirenz; epichlorhydrin; Michael addition; PEGylation

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