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International Journal of Pharmaceutical InvestigationNOW IN
Article

Polyethylene glycolated PAMAM dendrimers-Efavirenz conjugates

Suneela Pyreddy1★, Pandurangan Dinesh Kumar1, Palanirajan Vijayaraj Kumar2★ Corresponding author

  1. 1Department of Pharmaceutics, Hindu College of Pharmacy, Acharya Nagarjuna University, Guntur, Andhra Pradesh, INDIA.
  2. 2School of Pharmacy, University College Sadaya International University, JalanMenara Gading, Kuala Lumpur, MALAYSIA.

CORRESPONDENCE

Suneela Pyreddy

Department of Pharmaceutics, Hindu College of Pharmacy, Acharya Nagarjuna University, Guntur, Andhra Pradesh, INDIA.

dineshclbaid@gmail.com

Volume 4, Issue 1 · pp. 15–18 · PUBLISHED · DOI: 10.4103/2230-973X.127735

View on IJPI original site ↗

ABSTRACT

Aim:The preparation of novel PEGylated PAMAM (poly-amidoamine) dendrimers for delivery of anti-HIV drug Efavirenz is reported. Method and Materials: About 5.0 G PAMAM dendrimers are prepared by ethylene diamine core via Michael addition by divergent method. PEGylation is done by polyethylene glycol 600 using epichlorhydrin as linker. PEGylated 5.0 G PAMAM dendrimers loaded with Efavirenz (EFV) are evaluated for FTIR, DSC, SEM, drug release, and stability studies. Results and Conclusion:From the results it is proved that this method is less time consuming, inexpensive, and reproducible. Drug-release studies indicate, PEGylated 5.0 G PAMAM-EFV dendrimers have shown prolonged drugrelease property.

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    Pyreddy, S., Kumar, P. D., & Kumar, P. V. (). Polyethylene glycolated PAMAM dendrimers-Efavirenz conjugates. International Journal of Pharmaceutical Investigation, 4(1), 15–18. https://doi.org/10.4103/2230-973X.127735