Preparation and evaluation of chitosan microspheres containing nicorandil
Keyur S Patel1★, Mandev B Patel2★ Corresponding author
- 1Research Scholar, Department of Pharmaceutics, Bhagwant University, Ajmer, Rajasthan, INDIA.
- 2A-One Pharmacy College, Enasan, Ahmedabad, Gujarat, INDIA.
CORRESPONDENCE
Keyur S Patel
Research Scholar, Department of Pharmaceutics, Bhagwant University, Ajmer, Rajasthan, INDIA.
Volume 4, Issue 1 · pp. 32–37 · PUBLISHED · DOI: 10.4103/2230-973X.127738
ABSTRACT
Objectives:The objective of present study was to develop chitosan-based sustained release nicorandil microspheres to reduce the dosing frequency. Materials and Methods:The nicorandil-loaded chitosan microspheres were formulated by emulsion crosslinking method. A 32 factorial design was employed to study the infl uence of drug: Polymer ratio and volume of glutaraldehyde (GA) on percentage entrapment effi ciency, particle size, and % drug release at 8 h.Results: The entrapment effi ciency was found to be 41.67 ± 1.43-77.33 ± 1.97% and particle size range 65.67 ± 2.08-146.67 ± 2.18 μm. The batch CH5 showed 79.11 ± 2.23 and 96.21 ± 2.41% drug release at 8 and 12 h, respectively. Conclusions:Drug: Polymer ratio and volume of GA had signifi cant effect on % entrapment effi ciency, particle size, and % drug release. From the scanning electron microscopy (SEM) study observed that microspheres were spherical and fairly smooth surface. Fickian diffusion was the mode of drug release from nicorandil-loaded chitosan microspheres formulations.
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Patel, K. S., & Patel, M. B. (). Preparation and evaluation of chitosan microspheres containing nicorandil. International Journal of Pharmaceutical Investigation, 4(1), 32–37. https://doi.org/10.4103/2230-973X.127738