Volume 5, Issue 2

Original Research Article

1. Article

   Development of fl oating chitosan-xanthan beads for oral controlled release of glipizide

   Nilesh Kulkarni, Pravin Wakte, Jitendra Naik

   pp. 73–80 · DOI: 10.4103/2230-973X.153381

   Introduction: The aim of the present work was to develop controlled release, fl oating and mucoadhesive beads of glipizide by using the polyionic complexation technique. Plasma half-life of glipizide being 2–4 h was sele…

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2. Article

   Design and development and evaluation of candesartan cilexetil liquid filling formulations

   Y Deepthi, T. E. Gopalakrishna Murthy

   pp. 81–86 · DOI: 10.4103/2230-973X.153382

   Most of the currently available drugs are having poor water solubility and suffer from low oral bioavailability. One of the most promising approaches to deliver such insoluble drugs is by dissolving it in lipids, liquids…

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3. Article

   Effect of the moist-heat sterilization on fabricated nanoscale solid lipid particles containing rasagiline mesylate

   K. Viveksarathi, K. Kannan

   pp. 87–91 · DOI: 10.4103/2230-973X.153383

   Background:Nanoscale solid lipid particles of rasagiline mesylate (RM) were fabricated by microemulsion technique. The nanoscale particle must be sterile for intravenous administration, and several approaches are availab…

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4. Article

   Formulation and characterization of sustained release dosage form of moisture sensitive drug

   Priya Patel, Abhishek Dave, Amit Vasava, Paresh Patel

   pp. 92–100 · DOI: 10.4103/2230-973X.153385

   Objective:The purpose of this study was to prepare sustained release tablet of moisture sensitive drug like Ranitidine Hydrochloride for treatment of gastroesophageal reflux disease along with the improvement of moisture…

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5. Article

   Formulation of rizatriptan benzoate fast dissolving buccal fi lms by emulsion evaporation technique

   Suryadevara Vidyadhara, Reddyvallam Lankapalli Sasidhar, Thalamanchi Balakrishna, Malapolu Santha Vardhan

   pp. 101–106 · DOI: 10.4103/2230-973X.153387

   Aim:The present study deals with the formulation of fast dissolving fi lms of Rizatriptan benzoate that is used for the treatment of Migraine. The concept of fast-dissolving drug delivery emerged from the desire to provi…

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6. Article

   Chronomodulated drug delivery system of urapidil for the treatment of hypertension

   Sona S. Chaudhary, Hetal K. Patel, Punit B. Parejiya, Pragna K. Shelat

   pp. 107–113 · DOI: 10.4103/2230-973X.153389

   Introduction: Hypertension is a disease which shows circadian rhythm in the pattern of two peaks, one in the evening at about 7pm and other in the early morning between 4 am to 8 am. Conventional therapies are incapable …

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7. Article

   Solubility enhancement studies on lurasidone hydrochloride using mixed hydrotropy

   Jyotsana R. Madan, Kiran T. Pawar, Kamal Dua

   pp. 114–120 · DOI: 10.4103/2230-973X.153390

   Low aqueous solubility is a major problem faced during formulation development of new drug molecules. Lurasidone HCl (LRD) is an antipsychotic agent specially used in the treatments of schizophrenia and is a good example…

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