Article · Volume 8, Issue 1 · pp. 7–13

Design and investigation of metformin hydrochloride–Indion‑254 complex for dispersible tablets

Arlene Stuart Villarroel^1,2, Madan Mohan Gupta^2,3, Lexley M. Pinto Pereira¹, Andanappa K. Gadad²

¹Department of Pharmacology.
²School of Pharmacy, Faculty of Medical Sciences, The University of the West Indies.
³Laboratory of Pharmaceutical Formulation Design and Development, School of Pharmacy Faculty of Medical Sciences, The University of the West Indies, St. Augustine, Trinidad and Tobago, WEST INDIES.

Abstract

Objective: Metformin is a first‑line agent for the treatment of Type 2 diabetes. The taste of metformin hydrochloride drug powder is bitter and its formulation are orally used. The objective of this study was to make a complex of metformin hydrochloride with Indion‑254 resin for the purpose of preparation of dispersible tablet.Materials and Methods: This study formulated metformin hydrochloride–Indion‑254 complexes with different proportion of resin with fixed amount of drug as well as mixed at varying speed which improved the flowability.Results: The resulted complex was investigated by the help of Fourier Transform- Infrared Spectroscopy, differential scanning calorimetry, and X‑ray diffraction which were used to confirm complexation and to differentiate its features from the individual ingredients and the physical mixtures of ingredients.Conclusion: The formulated metformin hydrochloride–Indion‑254 complex showed better drug loading as well as good release in mixed phosphate buffer in 200 ml.

Keywords: Complex; drug dissolution; Indion‑254; metformin hydrochloride; taste masking

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