Design and investigation of metformin hydrochloride–Indion‑254 complex for dispersible tablets

ABSTRACT

Objective:Metformin is a first‑line agent for the treatment of Type 2 diabetes. The taste of metformin hydrochloride drug powder is bitter and its formulation are orally used. The objective of this study was to make a complex of metformin hydrochloride with Indion‑254 resin for the purpose of preparation of dispersible tablet. Materials and Methods: This study formulated metformin hydrochloride–Indion‑254 complexes with different proportion of resin with fixed amount of drug as well as mixed at varying speed which improved the flowability. Results: The resulted complex was investigated by the help of Fourier Transform- Infrared Spectroscopy, differential scanning calorimetry, and X‑ray diffraction which were used to confirm complexation and to differentiate its features from the individual ingredients and the physical mixtures of ingredients. Conclusion: The formulated metformin hydrochloride–Indion‑254 complex showed better drug loading as well as good release in mixed phosphate buffer in 200 ml.

KEYWORDS

• Complex
• drug dissolution
• Indion‑254
• metformin hydrochloride
• taste masking

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• DOI10.4103/jphi.JPHI_3_18Copy

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