Volume 8, Issue 3

Original Research Article

1. Article

   Study on the quality control analysis of antiepileptic drugs using high‑performance liquid chromatography

   Manzoor Ahmad Mir, Najwa Shabir, Umar Mehraj, Younis Mohd Rather, Samina Farhat

   pp. 115–121 · DOI: 10.4103/jphi.JPHI_45_18 · 2018

   Background:Epilepsy is the second most common neurological condition, and antiepileptic drugs(AEDs) are used as a prophylactic measure. Any amount of poor-quality medicine is unacceptable because it increases morbidity a…

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2. Article

   Anti‑osteoporotic activity of isoflavones from Iris germanica targeting NF‑kappaB

   Afroze Alam, Monika Verma, Kamlesh Kumar Naik, Disha Choudhary, Shailendra Kumar

   pp. 122–129 · DOI: 10.4103/jphi.JPHI_36_18 · 2018

   Background:Most of the available anti‑osteoporotic drugs are costly and possess great threat of severe side effects. Thus, an alternative approach is required to develop new therapeutic drugs. Materials and Methods: An a…

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3. Article

   Molecular docking studies of ephedrine, eugenol, and their derivatives as arginase inhibitors: Implications in asthma

   Suhasini Donthi, Jayasree Ganugapati, Vijayalakshmi Valluri, Ramesh Macha, Krovvidi S. R. Sivasai

   pp. 130–137 · DOI: 10.4103/jphi.JPHI_25_18 · 2018

   Background: Arginine being a common substrate for arginase and nitric oxide synthase (NOS) an imbalance between enzymes could lead to a shift in airway responses. Reports suggest that increased arginase reduces the subst…

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4. Article

   Synthesis, antimicrobial activity, and docking study of some N3 , N6 ‑diphenylpyridazine‑3,6‑diamine derivatives as dihydrofolate reductase inhibitors

   Athar Javed, Sameer Sapra, Afroze Alam

   pp. 138–144 · DOI: 10.4103/jphi.JPHI_37_18 · 2018

   Objective:The present study focussed on the synthesis of pyridazine analogs to explore broad‑spectrum antimicrobial study. Since pyridazine analogs are not conventionally found in nature, and hence, its analogs are studi…

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5. Article

   The effectiveness of Valeriana officinalis on sleep disturbance in patients with chronic heart failure

   Fatemeh Aliakbari, Mahmoud Rafieian

   pp. 145–150 · DOI: 10.4103/jphi.JPHI_43_18 · 2018

   Background:Sleep disturbances are common problems in patients with chronic heart failure (CHF) and are a significant contributing factor to fatigue and poor quality of life. The aim of the present study was to evaluate t…

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6. Article

   Intensive monitoring of adverse drug reactions to antipsychotic medications in the inpatient psychiatry department of a secondary care hospital of UAE

   Haneen Abou R Aburamadan, Sathvik Belagodu Sridhar, Talaat Matar Tadross

   pp. 151–156 · DOI: 10.4103/jphi.JPHI_46_18 · 2018

   Background: Antipsychotics are a class of medications used primarily for the treatment of psychotic disorders. However, these medications are associated with potential adverse drug reactions (ADRs). Aim: To monitor the i…

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