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IJPI · Lens · Antidiabetic Potential of Flavones on Streptozotocin-induced Diabetes Mellitus in Rat

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Article · Volume 9, Issue 4 · pp. 195–199

Antidiabetic Potential of Flavones on Streptozotocin-induced Diabetes Mellitus in Rat

Binish Inam1, Adil Inam1, Monika Verma2, Kamlesh Kumar Naik3, Afroze Alam4,5

  1. 1Department of Community Medicine, Narayan Medical College and Hospital, Jamuhar, Sasaram-Rohtas, Bihar, INDIA.
  2. 2Department of Paediatrics, Advanced Paediatrics Centre - PGIMER, Chandigarh, Punjab, INDIA.
  3. 3Department of Pharmaceutical Chemistry, Nandha College of Pharmacy, Perundurai, Main Road, Erode, Tamil Nadu, INDIA.
  4. 4Narayan Institute of Pharmacy, Gopal Narayan Singh University, Jamuhar, Rohtas (Sasaram), Bihar, INDIA.
  5. 5School of Pharmacy, Al-Karim University, Katihar-Purnia Road, Sirsa, Karim Bagh, Katihar, Bihar, INDIA.

Abstract

Objectives: The objective of the study was to develop new antidiabetic agents from synthetic route.Methods: An attempt was made to synthe- size various flavones. The structures of the compounds were elucidated by UV, IR, 1H-NMR and mass spectrometry. Furthermore, an in vivo antidiabetic activity study was carried out by streptozotocin induced model. Biochemical parameters were extensively studied to support anti-diabetic potential of synthesized flavones.Results: The study reveals that flavones such as F1, F2, F3, F5 and F8 were potentially considered for in-vivo anti- diabetic activity. Fasting blood glucose and biochemical parameters like to- tal protein, urea and creatinine, SGOT, SALP and SGPT were performed for the biological evaluation and compared with that of standard glibenclamide (5 mg/kg). Among the five consolidated flavones, F8 possess high signifi- cant (p < 0.01) results and restores the blood glucose level, liver enzymes and renal parameters. Based on these results, a promising potent drug would be developed in the management of diabetes mellitus.Conclusion: In-vivo evaluations of selected compounds were carried out for its anti- diabetic activity considering different biochemical parameters. Some of the selected flavones showed excellent and noticeable antidiabetic activity.

Keywords: Antidiabetic activity; Creatinine; Flavones; Total Protein; SGOT; SALP; SGPT; Streptozotocin

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