Article · Volume 11, Issue 2 · pp. 75–7

Ticagrelor-Induced Complete Heart Block: A Rare Entity

Wagle Varun Anand¹, Isha Khadke¹, R Padmakumar², M Sudhakar Rao², Bharti Chogtu¹

¹Department of Pharmacology Medicine, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India.
²Department of Cardiology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India.

Abstract

Ticagrelor, a purinergic P2Y12 receptor blocker, is a potent platelet antagonist and an important component in the treatment for acute coronary syndromes identified to have a potential risk to cause bradyarrhythmias. Here, we report the case of a diabetic patient of unstable angina with left bundle branch block who was prescribed ticagrelor post angioplasty. Electrocardiogram (ECG) revealed a complete heart block after about 1 week. Ticagrelor was stopped and replaced by clopidogrel. The patient became asymptomatic and ECG showed baseline rhythm after 1 week of stoppage of ticagrelor.

Keywords: Heart block; purinergic P2Y receptor antagonist; ticagrelor

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