Article · Volume 13, Issue 2 · pp. 190–196

Curcumin-Impregnated Drug Delivery Systems May Show Promise in the Treatment of Diseases Secondary to Traumatic Brain Injury: Systematic Review

İbrahim Yilmaz^1,2, Numan Karaarslan³, Hakan Somay⁴, Hanefi Ozbek⁵, Ozkan Ates⁶

¹Ministry of Health, Dr Ismail Fehmi Cumalioglu City Hospital, Unit of Pharmacovigilance and Rational Use of Drugs, Tekirdag, Turkey.
²Department of Medical Services and Techniques, Vocational School of Health Services, Istanbul Rumeli University, Istanbul, Turkey.
³Department of Neurosurgery, Halic University School of Medicine, Istanbul, Turkey.
⁴Department of Neurosurgery, Kadikoy Medicana Hospital, Istanbul, Turkey.
⁵Department of Medical Pharmacology, İzmir Bakırçay University School of Medicine, Izmir, Turkey.
⁶Department of Neurosurgery, Istanbul Koc University School of Medicine, Istanbul, Turkey.

Abstract

Objective: To find out whether curcumin can be effective in the treatment of traumatic brain injury (TBI).Methods: A comprehensive and systematic literature search in the PubMed electronic database was performed. Descriptive statistics were used to evaluate the data obtained. The results were presented as frequency and percentage (%) or amount.Results: Two clinical trials investigated curcumin for the treatment of TBI. One study tested curcumin in living mammalian subjects using an amyloLipid nanovesicle. In three studies, curcumin was investigated together with the drug delivery system for the treatment of TBI.Conclusion: Drug delivery systems prepared with nanomaterials may have a potential therapeutic effect in treating TBI by increasing neuroprotection because they can penetrate the central nervous system more rapidly.

Keywords: Curcumin; Nanodrug; Oxidative stress; Traumatic brain injury

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