Evaluation of Antidiabetic Activity of Abutilon crispum on Normal and Streptozotocin- induced Diabetic Albino Wistar Rats

Abstract

Background: Diabetes mellitus is a disorder that affects the majority of individuals in the world.Objectives: The objective of the current study is to estimate the antidiabetic effect of methanol extract of Abutilon crispum entire plant, which is broadly cultivated in India’s arid and desert areas. This current investigation aims to estimate the efficacy of methanol extract of A. crispum to prevent streptozotocin-induced diabetes mellitus in Albino Wistar strain rats.Materials and Methods: In the current examination, methanol extract of the whole plant of A. crispum with doses of 250 and 500 mg/kg/b.wt (body weight) is administered through the oral route to the streptozotocin-prompted diabetic animals where n = 6. We evaluated the differences in food and water intake, body weight levels, fasting glucose, and oral glucose tolerance test (OGTT). When methanol extract of A. crispum was used to evaluate the OGTT for diabetic animals, levels of glucose were found to be pointedly lower when administered with 500 mg/kg b.wt as this is compared to the control group. A. crispum had specifically declined the levels of glucose elevated in diabetic rats. A. crispum is a vital alternative source for managing blood glucose levels in diabetes mellitus that have increased during the condition and need to be further reduced by oral medications that cause hypoglycemia. Biochemical parameters were estimated as a part of the investigation.Results: The results demonstrated that the dried methanol extract of A. crispum (250 mg/kg/bwt and 500 mg/kg/bwt) considerably declined those levels of blood glucose during the treatment period when compared to glibenclamide (10 mg/kg), enhanced the metabolism, improved the health of animals and enhanced the OGTT.Conclusion: As a result, we can conclude that the whole plant of A. crispum methanol extract contains antidiabetic effects, as well as, hypoglycemic activities.

Keywords: Streptozotocin; Wistar rats; Abutilon crispum; control group; diabetes mellitus; hypoglycemic action