Article · Volume 2, Issue 3 · pp. 179–184
Comparative anti-ulcerogenic study of pantoprazole formulation with and without sodium bicarbonate buffer on pyloric ligated rat
Papiya Bigoniya1, A. Shukla1, C. S. Singh1, P. Gotiya1
- 1Department of Pharmacology, Radharaman College of Pharmacy, Radharaman Group of Institutions, Ratibad, Bhopal, Madhya Pradesh, India Research Paper.
Abstract
Objective: To compare the anti-ulcer activity of buffered pantoprazole tablet against plain pantoprazole in pyloric ligated rats.Materials and Methods: In vivo pyloric ligated ulcerogenesis model was used to assess the effect of buffered pantoprazole on the volume of the gastric content, pH, total and free acidity, and ulcerogenic lesion. Pantoprazole level in gastric content and concurrently in stomach tissue was assessed by High Performance Liquid Chromatography (HPLC) analysis.Results: Buffered tablet effectively increases the pH of the gastric content above 4 up to 6 h (P<0.001) protecting pantoprazole from acid degradation resulting in high concentration in the gastric content and stomach tissue.Conclusions: This study substantiates better, faster and prolonged bioavailability of pantoprazole-buffered tablet compared to plain pantoprazole.
Keywords: Buffered tablet; pantoprazole; proton pump inhibitors; pyloric-ligation ABSTRACT
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