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JPP · Lens · Antidepressant-like activity of Benincasa hispida fruits in mice: Possible involvement of monoaminergic and GABAergic systems

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Article · Volume 3, Issue 1 · pp. 60–61

Antidepressant-like activity of Benincasa hispida fruits in mice: Possible involvement of monoaminergic and GABAergic systems

Dinesh Dhingra1, Parul Joshi1

  1. 1Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar, Haryana, India.

Abstract

Depression is one of the major mental disorders affecting hundreds of millions of people all over the world. There is a constant need to identify newer antidepressants from plants. Benincasa hispida (Cucurbitaceae) fruits were selected for evaluating its antidepressant potential in mice. There is only one study showing the antidepressant-like effect of the methanolic extract (0.6 and 1 g/kg administered three times and only once, respectively) of B. hispida fruits in mouse forced swim test (FST). The study showed the antidepressant-like effect of the methanolic extract in FST only and the mechanisms responsible for this activity have not been studied.

Keywords: Research Letters

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