Calcium channel blocking activity of a dihydropyrimidine derivative (BKVIII) on rabbit’s aortic strip

Abstract

Test compound, 5‑Acyl‑6‑methyl‑4 (2′,3′‑methylenedioxy) phenyl‑2‑S‑ethyl‑1,4‑dihydropyrimidine have a calcium channel blocking activity and showed relaxant effect on aortic smooth muscle in higher doses as compared with Nifedipine. In order to ascertain the status of this compound as a drug, further studies are needed not only in other animals and tissue models but also in various pathophysiological models, since some drugs show more pronounced effect in disease and in pathophysiological models than in physiological conditions.

Keywords: Research Letter