Article · Volume 4, Issue 2 · pp. 145–148

Comparison of the postoperative analgesia of intravenous infusion of adenosine and fentanyl

Nagendra S. Chunduri¹, Tanveer Kollu², Venkateswarulu R. Goteki³, Kiran K. Mallela⁴, Krishnaveni Madasu⁵

¹Department of Oral and Maxillofacial surgery, BVU Dental College, Sangli, Maharashtra, India.
²SB Patil Dental College, Bidar, Karnataka, India.
³Pananeeya Table 1: Summed pain relief and pain intensity scores Drugs Mean TOPAR (±SD) Mean SPID (±SD) 8 h 24 h 8 h Aceclofenac 24.5 (±3) 72.7 (±8.54) 15.1 (±4.18) Diclofenac sodium 17.8 (±3) 58.4 (±12.4) 10.0 (±3.55) TOPAR=Total pain relief over; SPID=Summed PID over Table 2: Adverse events profile of study drugs Adverse event Aceclofenac Diclofenac sodium (n=25) (n=25) Nausea ‑ 2 Gastritis 1 3 Epigastric pain 1 4 Fluctuance 1 2 Indigestion 1 3 Hypersensitivity reactions 1 1 Dizziness 2 4 Total 7 19 Dental College, Hyderabad, India.
⁴Oral and Maxillofacial surgery, Kalinga Institute of Dental sciences, Bhubneswar, Odisha, India.
⁵Periodontics, GITAM Dental College, Vishakapatnam, Andhra Pradesh, India.

Abstract

Significantly higher pain and FLACC behavior scale score were observed with fentanyl at 2 hours as compared to adenosine 15‑50 µg/kg/min [Table 1]. Fentanyl and adenosine 15‑50 µg/ kg/min had shown significantly less FLACC behavior scale scores at 8 hours as compared to adenosine 4‑6 µg/kg/min [Table 1]. Patients with adenosine 15‑50 µg/kg/min were more or less comfortable during the first 8 hours of study, whereas fentanyl group patients were more comfortable after 12 hours as observed with FLACC scale. Fukunaga et al. (2003) also observed significantly reduced pain scores in their study with adenosine.

Keywords: Research Letter

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