Diclofenac induced acute renal failure in a decompensated elderly patient

Abstract

Non‑steroidal anti‑inflammatory drugs (NSAIDs) are one of the most commonly prescribed drugs in post‑operative period worldwide. Their nephrotoxic effects are documented and accounts for around 15.5% of all cases of drug induced renal failure. Acute renal failure following NSAIDs usage are reported in volume depleted patients which is further precipitated by co‑morbid conditions like hypertension and various drug interactions that increase plasma level of NSAIDs and worsens the condition. This highlights the importance of hydration in post‑operative period as well as assessment of co‑morbid conditions before administration of NSAIDs to prevent acute renal failure.

Keywords: Drug interaction; hypertension; volume depleted