Article · Volume 6, Issue 2 · pp. 98–99
Hypokalemia and rhabdomyolysis
Henrik Horwitz1, Vidar A. Woeien1, Linda Wiuff Petersen2, Espen Jimenez‑Solem1
- 1Departments of Clinical Pharmacology, Hospital, University of Copenhagen, Denmark.
- 2Internal Medicine, Bispebjerg Hospital, University of Copenhagen, Denmark.
Abstract
The adverse drug event manager of the Capital Region of Denmark received a report of a 65‑year‑old male with type II diabetes and long‑lasting treatment with indapamide. In addition, he had a history of a high consumption of licorice. For 2 weeks, the patient suffered from myalgia, which the general practitioner suspected to be polymyalgia rheumatica and referred him to the hospital. Initial blood samples revealed a reduced potassium concentration of 1.5 mmol/L (reference value: 6.6-4.6 mmol/L) and an elevated creatine kinase of 18,400 IU/L (reference value: 40-280 IU/L). We believe that the patient developed rhabdomyolysis due to severe hypokalemia, possibly induced by a pharmacodynamic interaction between licorice and indapamide.
Keywords: Hypokalemia; indapamide; licorice; rhabdomyolysis; side‑effects
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