Article · Volume 6, Issue 3 · pp. 179–181

Life‑threatening bradyarrhythmia with oral phenytoin overdose

Giridharan Srinivasan¹, Mukta Wyawahare¹, Pratheesh George Mathen¹, Dharanipragada K.¹

¹Subrahmanyam Department of Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.

Abstract

We report a case of a 41‑year‑old lady, who developed severe hypotension and sinus bradycardia, following oral consumption of 20 g of phenytoin and 500 mg of glibenclamide. She required high dose of inotropes and a temporary transvenous pacer for her hemodynamic instability. This life‑threatening cardiotoxicity of phenytoin could have been due to its interaction with sulphonylurea. It is imperative to be aware of drug interactions, due to which, life‑threatening cardiovascular manifestations following phenytoin toxicity can occur.

Keywords: Cardiotoxicity; glibenclamide; sulphonylurea

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