Carbamazepine‑induced hypertension: A rare case

Abstract

A 74‑year‑old female with trigeminal neuralgia developed hypertension after the initiation of carbamazepine therapy. The time sequence of start of the suspected drug and onset of hypertension are consistent with the diagnosis. The hypertension did not resolve with antihypertensive therapy or dose reduction of carbamazepine. Patient recovered after the carbamazepine therapy was discontinued. The positive rechallenge and positive dechallenge showed association of carbamazepine therapy with hypertension as its adverse effect. This is a rare case that we report of carbamazepine‑induced hypertension and this report may act as alerting mechanism to the health care professionals especially neurologists.

Keywords: Carbamazepine; hypertension; trigeminal neuralgia