Article · Volume 8, Issue 2 · pp. 50–3
Efficacy of Atorvastatin in Prevention of Contrast-induced Nephropathy in High-risk Patients Undergoing Angiography: A Double-blind Randomized Controlled Trial
Maaz Hussain Syed1, Prakash Narayan Khandelwal2, Vijay R. Thawani3, S. S. Katare4
- 1Department of Pharmacology, Indian Institute of Medical Science and Research and Noor Hospital, Jalna, India.
- 2Department of Pharmacology, Government Medical College and Hospital, Aurangabad, India.
- 3Department of Pharmacology, People’s College of Medical Sciences and Research Centre, Bhopal, India.
- 4Department of Pharmacology, Byramjee Jeejeebhoy Government Medical College and Sassoon General Hospital, Pune, Maharashtra, India.
Abstract
Objective: To evaluate the efficacy and safety of atorvastatin (ATN) 80 mg in the prevention of contrast medium- induced nephropathy (CIN) in high risk patients undergoing angiograph.Materials and Methods: This was a prospective, double-blind, two-arm, parallel group RCT. A total of 216 patients undergoing coronary angiography were screened, and 188 eligible patients were randomized to two treatment arms. Patients in Group A received tablet N-acetylcysteine (NAC) 1200 mg once daily, and patients in Group B received tablet atorvastatin 80 mg + NAC 1200 mg once daily, for 3 days before, and 2 days after angiography.Results: A total of 160 patients completed the trial. Postprocedure, nine and two CIN cases were found in Group A and B, respectively. The mean change in serum creatinine was 0.086 ± 0.168 in Group A and 0.021 ± 0.083 in Group B, which was statistically significant (P = 0.0289). Postprocedure, the estimated glomerular filteration rate was reduced by 19.52 in Group A and 13.55 in Group B (P = 0.003).Conclusion: This trial indicates the positive role of statins in preventive strategy against CIN along with NAC.
Keywords: Atorvastatin; contrast-induced nephropathy; N-acetylcysteine
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