Article · Volume 8, Issue 3 · pp. 148–150

Terlipressin-induced Peripheral Ischemic Gangrene in a Diabetic Patient

Phulen Sarma¹, Gaurav Muktesh¹, Narender Dhaka¹, Rakesh Ruhela¹, Abhishek Mishra¹, Rahul Singh¹, Saroj K. Sinha¹, Bikash Medhi¹, Rakesh Kochhar¹

¹Departments of Pharmacology and Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Abstract

Terlipressin is used commonly in the management of hepatorenal syndrome and acute variceal bleeding. Like its parent compound vasopressin, it is also notorious for its ischemic complications. Terlipressin-induced ischemic complications can virtually affect any part of the body, but the incidence of serious complications is less than its parent compound vasopressin. Here, we report a case of terlipressin-induced peripheral ischemic gangrene in a diabetic male, which ultimately led to death of the patient.

Keywords: Gangrene; hepatorenal syndrome; ischemic complication; terlipressin; variceal bleeding

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