Article · Volume 8, Issue 4 · pp. 177–81

Levosulpiride-induced Movement Disorders

Supriyo Choudhury¹, Koustav Chatterjee², Ravi Singh², Shantanu Shubham², Santosh Trivedi², Suparna Chatterjee², Hrishikesh Kumar²

¹Department of Neurology, RGC Research Centre, Institute of Neurosciences, Kolkata, West Bengal, India.
²Department of Pharmacology, Institute of Post Graduate Medical Education and Research, Kolkata, West Bengal, India.

Abstract

We reported a series of patients who presented with LSP-induced movement disorders specifically, dyskinetic movements. We have presented one case of LSP-induced parkinsonism and summarized ten cases of LSP-induced dyskinesia. The causality of the adverse drug reaction was assessed systematically using a validated rating system, and we extensively qualified the clinical presentation of each case of dyskinesia using a clinical rating scale. We described an unusual case of acute onset LSP-induced parkinsonism in a 56-year-aged female. The mean age of ten patients of LSP-induced dyskinesia was 65.3 years (standard deviation 10.4), and 25% of patients were female. They were consuming suspected medication for a median duration of 13 months (range 1–60 months). We noted LSP-induced dyskinesia was challenging to treat as its resolution is often incomplete even with adequate treatment.

Keywords: Adverse drug reaction; antipsychotic; dyskinesia; levosulpiride; movement disorders; parkinsonism

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