Synthesis and Screening for Analgesic and Anti-infl ammatory Activities of Some Novel Amino Acid-containing Bicyclo Compounds

Abstract

Diazabicyclo[4.3.1]decane derivatives are well known opioid receptor ligands, hence, we have developed a novel and simple method for the synthesis of 3, 4-diphenyl-2,5-diaza-bicyclo[4.3.1]deca-1(9),2,4,6(10),7-pentaene- 8-carbonyl chloride derivatives containing amino acid moieties. The compounds were structurally conÞ rmed with the help of TLC, IR, NMR, and LCMS spectra. All the title compounds were screened for analgesic activity by using the tail-ß ick method and for anti-inß ammatory activity by using the carrageenan-induced paw edema method using diclofenac sodium as a standard.

Keywords: Amino acids; analgesic- anti-inß ammatory activity; 2; 5-diaza bicyclo [4.3.1] compounds