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Recent articles
15 articles · what your feed deliversReview Article
Drug-Resistant Tuberculosis at the Crossroads: Molecular Insights and Next-Generation Therapeutics
Lingaraj Kariyaplar Marulasiddappa, Abhishek Pete Nagaraj, Purushotham Karadigere Nagaraju
Volume 18, Issue 3 · pp. 611–618 · 2026
Tuberculosis (TB) growing prevalence of drug-resistant strains Mycobacterium tuberculosis, it continues to major worldwide disease and a major public health concern. Emergence of Extensively Drug-Resistant (XDR-TB), Multidrug-Resistant (MDR-TB) tuberculosis has confounded…
DOI: 10.5530/jyp.20260061
Review Article
The Estrobolome-Epigenetic Inflammatory Axis in Menopause: A Multisystem Mechanistic Link to Chronic Disease
Rina Das, Swati Rana, Dinesh Kumar Mehta, Arush Sharma
Volume 18, Issue 3 · pp. 619–625 · 2026
Menopause is characterized by a progressive decline in ovarian estrogen production, resulting in immune dysregulation and a chronic low-grade inflammatory state known as inflammaging. Beyond hormonal deficiency, emerging evidence highlights the role of the Estrobolome-the…
DOI: 10.5530/jyp.20260080
Review Article
Nanotechnology-Driven Strategies for Enhanced Brain Drug Delivery: A Review of Bio-Nanoparticle Systems
Suraj Kumar, Pranita Jirvankar
Volume 18, Issue 3 · pp. 626–631 · 2026
The BBB is one of the biggest challenges in the treatment of neurological diseases, as it blocks more than 98% of drugs reaching the brain. In this review, current nanotech approaches to overcoming the BBB are compiled, including functionalized NPs (liposomes, polymeric NPs,…
DOI: 10.5530/jyp.20260171
Review Article
Artificial Intelligence in Pharmacovigilance: A Narrative Review of Global Regulatory Perspectives, Technological Evolution, and Emerging Challenges
Suriya Sundharesan, Sneha Raja, Reshma Suresh, Jayasutha Jayram, Sujatha Kuppusamy, Harini Vinayagam, Someshwaran Surendran, Tanmayee Paladugu
Volume 18, Issue 3 · pp. 639–645 · 2026
Pharmacovigilance plays a key role in public health-it helps us spot, assess, and prevent adverse drug reactions throughout a drug’s life on the market. This review takes a closer look at how AI is reshaping pharmacovigilance. It covers what’s new in AI-driven tools, what global…
DOI: 10.5530/jyp.20260144
Review Article
Therapeutic and Dermatological Potential of Ganoderma lucidum (Reishi/Lingzhi) in Cosmeceutical Formulations: A Comprehensive Review
Pankaj Sharma
Volume 18, Issue 3 · pp. 646–655 · 2026
Ganoderma lucidum (Reishi) is a widely utilized medicinal mushroom in Asia, recognized for its hepatoprotective, antioxidant, immunomodulatory, and anticancer properties. The present review aims to systematically evaluate its cosmeceutical potential by examining bioactive…
DOI: 10.5530/jyp.20260426
Review Article
Marine Algae-Derived Bioactive Compounds and Biomaterials: Pharmaceutical Applications and Therapeutic Advances in Medical and Dental Sciences
Sahana Shree Muthu, Shivasakthy Manivasakan, Vijayan Venugopal, Arumugam Muthuvel, David Livingstone
Volume 18, Issue 3 · pp. 656–661 · 2026
Marine algae and their derivatives have gained substantial notice in the scientific community because of their rich source of bioactive compounds, which include carbohydrates, lipids, proteins, and pigments. These compounds have shown promising applications in both medical and…
DOI: 10.5530/jyp.20260409
Review Article
Clozapine-Induced Myocarditis: A Systematic Review of Case Reports
Sanat Mahendra Dhoke, Mishthi Prajapati, Meensher Thapa Magar, Bipin Shaji
Volume 18, Issue 3 · pp. 662–669 · 2026
Clozapine-Induced Myocarditis (CIM) is a rare but potentially life-threatening adverse drug reaction linked with the use of clozapine in treatment-resistant. The aim of this systematic review is to recognise the clinical features, diagnostic findings, and clozapine rechallenge…
DOI: 10.5530/jyp.20260255
Review Article
A Narrative Review on Siddha Dietetics (Pathiyam) and its Pharmacological Relevance in Diabetes Care
Gayatri Raveendran, Ramamurthy Murugan, Suruthi Kanaga Rathina, Priya B Krishnamoorthy, Shanmugapriya Ponnappan, G Senthilvel
Volume 18, Issue 3 · pp. 670–675 · 2026
Diabetes Mellitus has become a global burden with features of hyperglycemia as a result of insulin resistance, impaired insulin secretion or both. Dietetics plays an important role in both the management and prevention of conditions like Diabetes. Traditional Indian System of…
DOI: 10.5530/jyp.20260175
Review Article
APOE ε4 Modifies Stage-Dependent Alterations in Circulating Brain-Derived Neurotrophic Factor Across the Alzheimer’s Disease Continuum: A Systematic Review and Meta-Analysis
BS Sachin, Radhakrishnan Narayanaswamy, Anshu Kumar Yadav, Biswajit Das, V Shree Harsha, Kshama Nadig
Volume 18, Issue 3 · pp. 676–685 · 2026
Circulating Brain-Derived Neurotrophic Factor (BDNF) has been proposed as a blood-based marker of synaptic vulnerability in Alzheimer’s Disease (AD), but published findings vary across disease stages and cohorts. This review and meta-analysis examined whether APOE ε4 carrier…
DOI: 10.5530/jyp.20260221
Original Article
Screening of Bioactive Phytochemicals from Gentiana kurroo for Diabetes Management: An Integrated Molecular Docking and in vitro Enzyme Inhibition Study
Pankaj Sharma
Volume 18, Issue 3 · pp. 686–692 · 2026
Background Diabetes mellitus is a multifactorial metabolic disorder requiring multi-target therapeutic strategies. Medicinal plants rich in bioactive phytochemicals represent promising alternatives to conventional antidiabetic drugs. Gentiana kurroo, an endangered Himalayan…
DOI: 10.5530/jyp.20260310
Original Article
Medhya Rasayana Ghrita to Phytosome Approach-Centella asiatica and Bacopa monnieri Bioactive Enriched Fractions
Sharada Deore, Bhushan Arun Baviskar, Ram Chhatrapati Vighne
Volume 18, Issue 3 · pp. 693–701 · 2026
Background Phytosomes overcome solubility, absorption, and stability limitations of crude extracts, leading to enhanced bioavailability, better therapeutic effect, and reduced required dose. Purpose Conventional Ayurvedic formulations of Centella asiatica and Bacopa monnieri are…
DOI: 10.5530/jyp.20260039
Original Article
GC-MS Profiling of Caulerpa lentillifera Hot Water Extract and it’s in vitro Effects on Hepatocellular Carcinoma Cell Progression
Nuranis Syazwani Shaiful Hambry, Mohd Nizam Mordi, Shahrul Bariyah Sahul Hamid
Volume 18, Issue 3 · pp. 702–708 · 2026
Background Hepatocellular Carcinoma (HCC) is a highly resilient cancer associated with poor survival outcomes. Current treatment with sorafenib inhibits Raf kinases but still encounter resistance mediated by alternative survival pathways. Caulerpa lentillifera (C. lentillifera)…
DOI: 10.5530/jyp.20260081
Original Article
Design, Synthesis and Molecular Dynamics Simulation of Novel Spiropyran Derivatives as Putative CDK6-Targeting Anticancer Agents for Breast Cancer Treatment
Sagar D. Magar, Shubham P. Mankar, Sanket K. Tambe, Amol S. Dighe, Nilima M. Wani, Mayur S. Bhosale, Rahul K. Godge, Dattaprasad N. Vikhe, Jagdish R. Kudnar
Volume 18, Issue 3 · pp. 709–719 · 2026
Background Breast cancer treatment with current dual CDK4/6 inhibitors is limited by hematological toxicity and acquired drug resistance. CDK6 is overexpressed in specific breast cancer subtypes and represents a validated molecular target for the development of new anticancer…
DOI: 10.5530/jyp.20260236
Original Article
Antimicrobial Evaluation, LC-MS Characterization and Computational Molecular Study of Ethanol Extract of Marine Macro Algae Sargassum tenerrimum J. Agardh
Mohamed Ishal Manningapatt, Muralidharan Palayyan
Volume 18, Issue 3 · pp. 720–726 · 2026
Objectives The current research was aimed to assess the antimicrobial activity and LC-MS characterization, and computational molecular analysis of the ethanolic extract of marine macro algae Sargassum tenerrimum J. Agardh. Materials and Methods Marine macro algae S. tenerrimum…
DOI: 10.5530/jyp.20260274
Original Article
Biological and Safety Evaluation of Green-Synthesized Calcium Oxide Nanoparticles Using Hedyotis diffusa
Kaniga Pandi, Binoy Varghese Cheriyan, Jayasri Bantaram, Indhumathi Jagan, Mahalakshmi Sundarraj, Subha Pradhaa Ramachandran, Preethi Harikrishnan, Sharmila Sakthisivanandhan, Arunpandiyan Jeyakumar, Inigo Pathuvairajan, Mathesvaran Thirunavukarasu, Bhavya Ekambaram
Volume 18, Issue 3 · pp. 727–740 · 2026
Background Dental caries and periodontal diseases are among the most prevalent oral disorders worldwide, necessitating the development of safe and effective therapeutic approaches. Green-synthesized nanoparticles derived from medicinal plants offer enhanced biocompatibility and…
DOI: 10.5530/jyp.20260014