Volume 18, Issue 3

Lingaraj Kariyaplar Marulasiddappa, Abhishek Pete Nagaraj, Purushotham Karadigere Nagaraju

pp. 611–618 · DOI: 10.5530/jyp.20260061 · 2026

Tuberculosis (TB) growing prevalence of drug-resistant strains Mycobacterium tuberculosis, it continues to major worldwide disease and a major public health concern. Emergence of Extensively Drug-Resistant (XDR-TB), Mult…

Rina Das, Swati Rana, Dinesh Kumar Mehta, Arush Sharma

pp. 619–625 · DOI: 10.5530/jyp.20260080 · 2026

Menopause is characterized by a progressive decline in ovarian estrogen production, resulting in immune dysregulation and a chronic low-grade inflammatory state known as inflammaging. Beyond hormonal deficiency, emerging…

Suraj Kumar, Pranita Jirvankar

pp. 626–631 · DOI: 10.5530/jyp.20260171 · 2026

The BBB is one of the biggest challenges in the treatment of neurological diseases, as it blocks more than 98% of drugs reaching the brain. In this review, current nanotech approaches to overcoming the BBB are compiled, …

Suriya Sundharesan, Sneha Raja, Reshma Suresh, Jayasutha Jayram, Sujatha Kuppusamy, Harini Vinayagam, Someshwaran Surendran, Tanmayee Paladugu

pp. 639–645 · DOI: 10.5530/jyp.20260144 · 2026

Pharmacovigilance plays a key role in public health-it helps us spot, assess, and prevent adverse drug reactions throughout a drug’s life on the market. This review takes a closer look at how AI is reshaping pharmacovigi…

Pankaj Sharma

pp. 646–655 · DOI: 10.5530/jyp.20260426 · 2026

Ganoderma lucidum (Reishi) is a widely utilized medicinal mushroom in Asia, recognized for its hepatoprotective, antioxidant, immunomodulatory, and anticancer properties. The present review aims to systematically evaluat…

Sahana Shree Muthu, Shivasakthy Manivasakan, Vijayan Venugopal, Arumugam Muthuvel, David Livingstone

pp. 656–661 · DOI: 10.5530/jyp.20260409 · 2026

Marine algae and their derivatives have gained substantial notice in the scientific community because of their rich source of bioactive compounds, which include carbohydrates, lipids, proteins, and pigments. These compou…

Sanat Mahendra Dhoke, Mishthi Prajapati, Meensher Thapa Magar, Bipin Shaji

pp. 662–669 · DOI: 10.5530/jyp.20260255 · 2026

Clozapine-Induced Myocarditis (CIM) is a rare but potentially life-threatening adverse drug reaction linked with the use of clozapine in treatment-resistant. The aim of this systematic review is to recognise the clinical…

Gayatri Raveendran, Ramamurthy Murugan, Suruthi Kanaga Rathina, Priya B Krishnamoorthy, Shanmugapriya Ponnappan, G Senthilvel

pp. 670–675 · DOI: 10.5530/jyp.20260175 · 2026

Diabetes Mellitus has become a global burden with features of hyperglycemia as a result of insulin resistance, impaired insulin secretion or both. Dietetics plays an important role in both the management and prevention o…

BS Sachin, Radhakrishnan Narayanaswamy, Anshu Kumar Yadav, Biswajit Das, V Shree Harsha, Kshama Nadig

pp. 676–685 · DOI: 10.5530/jyp.20260221 · 2026

Circulating Brain-Derived Neurotrophic Factor (BDNF) has been proposed as a blood-based marker of synaptic vulnerability in Alzheimer’s Disease (AD), but published findings vary across disease stages and cohorts. This re…

Pankaj Sharma

pp. 686–692 · DOI: 10.5530/jyp.20260310 · 2026

Background Diabetes mellitus is a multifactorial metabolic disorder requiring multi-target therapeutic strategies. Medicinal plants rich in bioactive phytochemicals represent promising alternatives to conventional antidi…

Sharada Deore, Bhushan Arun Baviskar, Ram Chhatrapati Vighne

pp. 693–701 · DOI: 10.5530/jyp.20260039 · 2026

Background Phytosomes overcome solubility, absorption, and stability limitations of crude extracts, leading to enhanced bioavailability, better therapeutic effect, and reduced required dose. Purpose Conventional Ayurvedi…

Nuranis Syazwani Shaiful Hambry, Mohd Nizam Mordi, Shahrul Bariyah Sahul Hamid

pp. 702–708 · DOI: 10.5530/jyp.20260081 · 2026

Background Hepatocellular Carcinoma (HCC) is a highly resilient cancer associated with poor survival outcomes. Current treatment with sorafenib inhibits Raf kinases but still encounter resistance mediated by alternative …

Sagar D. Magar, Shubham P. Mankar, Sanket K. Tambe, Amol S. Dighe, Nilima M. Wani, Mayur S. Bhosale, Rahul K. Godge, Dattaprasad N. Vikhe, Jagdish R. Kudnar

pp. 709–719 · DOI: 10.5530/jyp.20260236 · 2026

Background Breast cancer treatment with current dual CDK4/6 inhibitors is limited by hematological toxicity and acquired drug resistance. CDK6 is overexpressed in specific breast cancer subtypes and represents a validate…

Mohamed Ishal Manningapatt, Muralidharan Palayyan

pp. 720–726 · DOI: 10.5530/jyp.20260274 · 2026

Objectives The current research was aimed to assess the antimicrobial activity and LC-MS characterization, and computational molecular analysis of the ethanolic extract of marine macro algae Sargassum tenerrimum J. Agard…

Kaniga Pandi, Binoy Varghese Cheriyan, Jayasri Bantaram, Indhumathi Jagan, Mahalakshmi Sundarraj, Subha Pradhaa Ramachandran, Preethi Harikrishnan, Sharmila Sakthisivanandhan, Arunpandiyan Jeyakumar, Inigo Pathuvairajan, Mathesvaran Thirunavukarasu, Bhavya Ekambaram

pp. 727–740 · DOI: 10.5530/jyp.20260014 · 2026

Background Dental caries and periodontal diseases are among the most prevalent oral disorders worldwide, necessitating the development of safe and effective therapeutic approaches. Green-synthesized nanoparticles derived…

Pooja Singh, Bhavna Kumar, Santosh Kumar Verma

pp. 741–754 · DOI: 10.5530/jyp.20260381 · 2026

Background Tuberculosis treatment requires prolonged multidrug therapy, often associated with poor patient compliance and systemic side effects. The present study aimed to develop and optimize a Poloxamer 407-based therm…

Koushik Yetukuri, Sethu Chandra Kanth Annavarapu, Venkata Jaswanth Balla, Vasudeva Bellana, Avinash Chowdary Chirumamilla, Siva Pradeep Raparla

pp. 755–762 · DOI: 10.5530/jyp.20260186 · 2026

Background The design and optimization of a Tinospora cordifolia (Giloy) extract-loaded topical gel was carried out to explore its anti-inflammatory potential using a Box-Behnken Design (BBD). The study focused on improv…

SVVNSM Lakshmi, S Dinesh Mohan, B Varsha, G Mythri, B Srimukhi

pp. 763–769 · DOI: 10.5530/jyp.20260209 · 2026

Background Increasing safety concerns regarding synthetic colorants have promoted the development of herbal cosmetic formulations. Butea monosperma flowers are rich in natural pigments and bioactive compounds suitable fo…

Deepak Raja Arulmozhi, Pooja Sathishkumar, Subramanian Somaskanthan

pp. 770–778 · DOI: 10.5530/jyp.20260147 · 2026

Background Diabetic Retinopathy (DR) and Diabetic Macular Edema (DME) require effective posterior segment drug delivery, challenged by ocular anatomical barriers. Triamcinolone Acetonide (TA) despite its intravitreal eff…

Baisnabdas Pathak, Saptarshi Samajdar, Deepshikha Datta, Bimal Das

pp. 779–785 · DOI: 10.5530/jyp.20260332 · 2026

Background Polysaccharides from nature have attracted significant interest as biocompatible and eco-friendly polymers used as carriers in drug delivery systems. ZMBP, which stands for Ziziphus mauritiana fruit pulp polys…