Article · Volume 10, Issue 1 · pp. 32–36

Formulation and Characterization of pH based Stimuli Sensitive based Hydrogels for the Treatment of Ocular Infection

Nagalakshmi Sethuraman¹, Anbarasan Balu¹, Ramesh Selvaraj¹, Thanka Johnson², Shanmuganathan Seetharaman¹

¹Faculty of Pharmacy, Department of Pharmaceutics, Sri Ramachandra Medical College and Reserach Institute, Porur, Chennai, Tamil Nadu, INDIA.
²Department of Pathology, Sri Ramachandra Medical College and Research Institute, Porur, Chennai, Tamil Nadu, INDIA.

Abstract

Objective: The goal of the study was to formulate and characterized the pH stimuli sensitive based hydrogels for the effective treatment of infected eye.Method: Simple method of preparation was adapted.Result: The optimized formulations was undergone the characterization studies such as XRD spectrum analysis, FTIR analysis, Gelling capacity, Drug content, Determination of viscosity, surface tension of the optimized formulations, DSC analysis, in-vitro release study of the optimized formulations, Ex-vivo release studies of best formulation and stability studies. The pre-formulation studies confirm the drug and polymer are compatible with each other. The F5 formulation showed the maximum percentage of drug release around 97.08% in drug release study. The ex-vivo study showed 95.57% of drug release for the period of 7h. Further, the optimized formulations were most stable in room temperature when compared to higher temperature.Conclusion: The prepared formulations of pH based hydrogels were optimized; developed formulations are used as treatment for ocular drug delivery system with increase in precorneal time, reduced frequency of the dosage and to achieve the patient compliance.

Keywords: Hydrogels; Viscosity; Ex-vivo study; Stimuli; Sensitive; Gelling Capacity

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