Effects of Bungur Leaves (Lagerstroemia speciose (L.) Pres.) on Malondialdehyde and Blood Glucose Levels in Hyperglycemic Mice

Abstract

Background: Bungur leaves have saponins, tannins, ellagitannin and flavonoids that could function as antioxidant and antihyperglycemic. Bungur leaves also consumed in Indonesia people for their diabetes treatment for a long time.Objective: The aim of this research is to know bungur leaves as antioxidant and antihyperglycemic so that can be used in the alternative therapy of diabetes mellitus.Methods: Mice were made hyperglycemic using alloxan, except normal group. The study was carried out using 30 mice divided into 6 groups: normal group, negative group, positive group, and treated group with 3 dose variation from bungur leaves decoction and taken the data on day 0, 5, and 19.Results: The result in normal group, negative group (alloxan), positive group (glibenclamide), treatments group which given by doses 1.6 g/kgBW, 3.2 g/kgBW, 6.4 g/kgBW of MDA levels respectively 0.6993 nmol/mL; 4.1953 nmol/mL; 0.8462 nmol/mL; 4.2873 nmol/mL; 3.3700 nmol/mL; 2.0670 nmol/mL while blood glucose levels on 19th day respectively 107.6 mg/dL;149.2 mg/dL; 104 mg/dL; 93 mg/dL; 109.6 mg/dL; 104 mg/dL. MDA levels on 6.4 g/kgBW and the averages of MDA levels have different significantly with a positive group, while blood glucose levels showed all treatments groups doses has no different significantly with positive group analyzed statistically.Conclusion: Bungur leaves have an effect to decrease MDA levels but not as well as glibenclamide while they have an effect to decrease blood glucose as well as glibenclamide.

Keywords: Anti hyperglycemic; Antioxidant; Bungur; Glibenclamide; Hyperglycemic mice