Article · Volume 10, Issue 4 · pp. 489–490
A Case Report on Cilostazol Induced Loss of Diabetic Control
Dilip Chandrasekhar1, Nizar Mohamed Kanjhiraparambil1, Drisya Rajan Chalappurath1
- 1Department of Pharmacy Practice, Al Shifa College of Pharmacy, Perinthalmanna, Kerala, INDIA.
Abstract
A 69-year-old male with known case of diabetes mellitus and hypertension was admitted with wet gangrene of right greater toe. He received cilostazol 100mg twice a day for 3 days. During this period, there was a marked elevation of blood sugar requiring higher dosage of insulin. Upon withholding the suspected drug there was a marked fall in blood glucose levels indicating a positive dechallenge. Cilostazol might have loss of diabetic control by favouring intestinal glucose absorption through increased cAMP levels and GLUT2 expression necessitating management with higher dosage of insulin.
Keywords: Cilostazol; Wet gangrene; Hyperglycemia; Diabetes mellitus
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