Quality Standard of Safoof razyanaj: A Unani Polyherbal Powder Formulation

Abstract

Objectives: Safoof razyanaj (SR) a Unani polyherbal powder formulation used in dyspepsia, distension of stomach and anorexia. Standardization data of SR. by using scientific analytical procedures was established.Methods: Cleaned and dried powder of plant drug was prepared as per the method described in Unani Pharmacopeia of India (UPI). SR formulation was evaluated using physicochemical tests: powder characterization, extractive value, alcohol and water-soluble matter, Ash value, LOD at 105°C, pH and HPTLC fingerprinting.Results: SR color was light brown, aromatic and sweetish in taste. Physicochemical parameters expressed as mean values of the three readings showed loss of weight on drying, total ash, acid insoluble ash and watersoluble ash as 4.62 ± 0.10, 4.95 ± 0.05, 1.83 ± 0.03 and 2.10 ± 0.03 respectively. The Bulk density, tapped density, angle of repose, Hauser’s ratio and compressibility index were 0.46 ± 0.01, 0.56 ± 0.00, 35.62 ± 0.45, 1.23 ± 0.00 and 19.24 ± 0.59 respectively, pH of 1% and 10% solution were 4.78 ± 0.03 and 5.08±0.02 respectively. Extractive values in petroleum ether, benzene and ethyl alcohol by successive extraction method were 11.24 ± 0.14, 2.08 ± 0.04 and 6.73 ± 0.10 respectively. Extractive values in petroleum ether, benzene, ethyl alcohol and water by non-successive extraction method were 11.24 ± 0.14, 15.44 ± 0.24, 32.20 ± 0.13 and 34.28 ± 0.18 respectively. Qualitative analysis showed presence of alkaloid, tannin, terpenoid, protein, carbohydrate, phenol, glycoside, flavonoid and saponin. HPTLC fingerprinting data of SR in methanolic extract and mobile phase toluene: ethyl acetate: formic acid (5:4:1) was set in.Conclusion: Standardization data of SR was obtained.

Keywords: Safoof razyanaj; Standardization; Unani; Powder; Formulation