Drug Utilization Pattern in Chronic Kidney Disease Associated Comorbidities at a Tertiary Care Hospital

Abstract

Background: Patients with Chronic Kidney Disease (CKD) with multiple Comorbidities like Hypertension, Diabetes, and Anemia require Numerous Drugs. Multiple drugs Predispose to Potential drug-drug Interactions, which increase hospital stay, health care expenses, and ultimately morbidity and mortality. So, we aim to study the drug utilization pattern in CKD-associated comorbidities at a tertiary care hospital.Materials and Methods:A HospitalBased Observational and Cross-Sectional study was conducted among patients with CKD-associated comorbidities enrolling IPD, OPD, and medicine ward patients for one year. The data collection form noted details like Socio-Demographic and clinical characteristics, past medication history, Comorbidities, and current medications. Drugs were categorized according to the Food and Drug Administration (FDA) and rationality score per the World Health Organization (WHO).Results: A total of 100 patients were analyzed. The mean age of the patients was 55.8, out of which 69% as male maximum patients belong to stage 5 72%. Hypertension was the most prevalent comorbidity followed by diabetes and calcium channel blockers (33.3%), insulin (soluble) 33.8% and erythropoietin (51%) were the most frequently prescribed drugs for the treatment of hypertension, diabetes, and Anemia, respectively. Mainly prescribed antibiotics belong to the Beta-Lactamase (26.6%) Penicillin Class.Conclusion: This study's results showed that CKD was more prevalent in males and that the highest number of patients had end-stage renal disease. CKD patients are concomitantly affected by hypertension, diabetes, CVD, and Anemia. Calcium channel blockers, Insulin, and Erythropoietin were the most frequently prescribed drugs.

Keywords: Drug utilization pattern; Chronic Kidney Disease; Hypertension; Diabetes; Anemia; Comorbidities