Serum Fructosamine and Glycosylated Haemoglobin in Diabetic Subjects and their Non-Diabetic First-Degree Relatives

Abstract

Aim: To Assess Serum fructosamine and glycosylated haemoglobin in diabetic subjects and their non-diabetic first-degree relatives, a comparative evaluation.Background: Glycosylated Hemoglobin has been used for decades for the diagnosis of diabetes. However, it is altered in situations including red blood cell wall defects, hemoglobinopathies and chronic renal failure. Therefore, the utility of short-term glycemic markers like serum fructosamine is gaining popularity.Objectives: The objective of this research is to assess Serum fructosamine levels in patients with Type II diabetes and their non-diabetic first-degree relatives.Materials and Methods: This research enrolled 300 participants. Group A comprised 100 diabetic patients, Group B contained 100 non-diabetic first-degree relatives (test group) of type II diabetic patients and 100 healthy controls with no immediate family history of Diabetes Mellitus were included in Group C.Results: Fasting blood sugar, postprandial sugar, glycosylated hemoglobin, serum fructosamine levels and fasting insulin levels were tested in each case. The Serum Fructosamine levels (362.95±71.06 μmol/L) and HbA1c (8.59±1.99%) were raised in diabetes patients. The fasting blood sugar and postprandial blood glucose and glycated hemoglobin levels were within the target levels in the first-degree relatives. There is a noteworthy difference in serum fructosamine levels between test and controls at p<0.05.Conclusion: Serum fructosamine can be used as a more robust marker than glycated hemoglobin for the early detection of diabetes in firstdegree relatives.

Keywords: Type II diabetes mellitus; Serum fructosamine; HbA1c; First-Degree relatives; HOMA-IR