A Systematic Review: Antihyperglycemic Properties of Catharanthus roseus Linn.

Abstract

Background: Diabetes mellitus is a term for several diseases that affect how your body regulates blood sugar. Ayurveda has long used Catharanthus roseusLinn., to cure diabetes. This review aims to summarise existing scientific studies investigating this plant's potential to manage diabetes.Methodology: The review concentrated on current, significant research that was discovered using academic databases such as PubMed, SpringerLink, Web of Science and Google Scholar and that addressed the antihyperglycemic and antidiabetic effects of C. roseus. Only English Original Artciles from January 2001 to May 2024 were included in the analysis.Results: After reviewing 192 publications from January 2001 to May 2024, this article focus to 15 research studies on the effects of C. roseuson blood sugar regulation and diabetes management.Conclusion: Interestingly, all the studies concurred that C. roseusappeared to have blood sugar-lowering effects in the test subjects. This potential antidiabetic benefit may be due to the plant's ability to Increase insulin production from previously impaired beta cells in response to glucose and enhance the activity of genes involved in sugar uptake (GLUT-2 and GLUT-4).

Keywords: Antidiabetic; Catharanthus roseus; Diabetes management; Streptozotocin; Vinca rosea