Exploring the Potential of 5-HT1 Receptor Subtypes as Therapeutic Targets for Obesity Treatment in Animal Models

Abstract

Background: Serotonergic system plays an important role in the energy balance evidenced by various studies. The present study was designed to investigate the involvement of 5-HT1 receptor subtype in experimental obesity.Materials and Methods: In the present study effects of chronic administration of eletriptan (2.5 and 10 mg kg-1 day-1, .p.o) specific 5-HT1receptor agonist for 8 weeks along with high fat diet to the obese rats which were pre-treated with high fat diet feeding for 8 weeks on the various parameters of obesity were analysed.Results: Treatment with eletriptan (2.5 and 10 mg kg-1 day-1, .p.o) produced significant dose dependent decrease (p<0.05) in various parameters of obesity as compared to high fat diet group. Eletriptan positively modulate the parameters of obesity. The present data demonstrated that high fat diet induced obesity was prevented by 5-HT receptor agonist eletriptan.Conclusion: Above findings give the strong evidence of involvement of 5-HT1 receptor subtype in obesity.

Keywords: Serotonergic System; Eletriptan; 5-Ht1receptor Agonist; Obese Rats; High Fat Diet