Article · Volume 4, Issue 2 · pp. 78–81

Changes in Serum Electrolytes, Urea, and Creatinine in Aloe Vera-treated Rats

Saka WA¹, Akhigbe RE¹, Popoola OT¹, Oyekunle OS¹

¹Department of Physiology, College of Health Sciences, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, NIGERIA.

Abstract

This study was carried out to investigate the effect of Aloe vera extract (AvE) on serum electrolytes, urea, and creatinine as indices of renal function in Sprague-Dawley rats. Twelve male Sprague-Dawley rats weighing between 80 and 130 g were used. Rats were divided into two groups: The control and the test groups (n=6). The test group received 1 ml of AvE daily for 28 days. Both the groups fed on standard rat chow and water ad libitum. The results showed a decrease in serum levels of sodium, and potassium, but an increase in the serum levels of bicarbonate, urea, and creatinine in the test group. The changes seen were, however, statistically insignificant, except for the serum levels of sodium and creatinine (P<0.05). It is thus concluded that AvE impairs renal handling of electrolytes with consequent hyponatremia and hypercreatinemia. However, this might be of therapeutic value in conditions associated with hypernatremia.

Keywords: Aloe vera; creatinine; electrolytes; kidney; urea

The full text of this article is available as a PDF. Open the PDF.