Evaluation of Clinical Efficacy of Metformin Therapy in Polycystic Ovary Syndrome

Abstract

Objective: To evaluate the metformin efficacy in Polycystic Ovary Syndrome (PCOS), intent to regulate the menstrual cycle and achieving pregnancy rate (live birth, stillbirth) in infertile women with PCOS proportions experiencing spontaneous abortion and time of pregnancy and investigation of the neonatal out comes.Methods: The cross sectional observational study was conducted between January 2012 and December 2014. Totally 310 patients with PCOS in the age group of 18 to 35 enrolled in the study and 220 patients with PCOS were included in the study. Evaluation included the collection of laboratory data, efficacy assessment of hirsutism, acne in PCOS and pre and post therapy of metformin in abortion rate, malformation and live birth rates.Result: Totally 101 subjects had a symptoms of acne and 117 subjects were had symptoms of hirsutism. Metformin therapy significantly reduced incidence of acne and hirsutism. Metformin therapy also significantly increased the number of conceptions from 112 to 138 and reduced abortion and malformation rates.Conclusion: This study has shown a consistent efficacy of metformin in PCOS of patients and improves the live birth rates. Thus, it demonstrates that the therapy of metformin was efficient and well tolerated, especially in teritoginicity and resumes the menstrual cyclicity and reduces the acne and hirsutism in PCOS patients.

Keywords: Acne; Hirsutism; Metformin; Pregnancy; Polycystic Ovary Syndrome