Communication · Volume 9, Issue 2 · pp. 296–298
In vivo Study of Tetraprenyltoluquinone, An Anticancer Compounds from Garcinia cowa Roxb
Fatma Sri Wahyuni1, Lim Siang Hui2, Johnson Stanslas3, Nordin Hj Lajis4, Dachriyanus d1
- 1Faculty of Pharmacy, Andalas University, Kampus Limau Manis, Padang, West Sumatra, INDONESIA.
- 2CARIF (Cancer Research Institute Foundation), MALAYSIA.
- 3Faculty of Medicine and Health Sciences, Universiti Putra Malaysia 43400 UPM, Serdang, Selangor, MALAYSIA.
- 4Laboratory of Natural Products, Institut of Bioscience, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, MALAYSIA.
Abstract
Objective: To investigate the in vivo antitumor effect of TPTQ against H-460 lung cancer cell lines in nude mice.Materials and Methods: Female nude mice bearing H-460 tumor at size approximately 5 mm in diameter were treated with a single intraperitoneal dose 800 mg/kg of TPTQ. The vehicle treated (10% tween 80) animals were used as control group. The tumor size and mice body weight were measured for 14 days.Results:Single treatment of 800 mg/kg of TPTQ displayed moderate antitumor activity against H-460 tumor xenografts as compared with vehicle-treated control. The mean time to reach RTV of 4 for vehicle-treated control group was 4.5 days whereas for TPTQ-treated (800 mg/kg) group was 9.5 days.Conclusion: The results showed that TPTQ slowed the tumor growth by 5 days. Thus, TPTQ may be considered as a promising compound in cancer chemotherapy.
Keywords: Tetrapreniltoluquinone; Lung cancer; Nude mice; H-460; Xenografts
The full text of this article is available as a PDF. Open the PDF.