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Recent articles
15 articles · what your feed deliversOriginal Article
Medicinal Plant Extracts as Potential β-Lactamase Inhibitors: Integrated Evaluation of β-Lactamase Enzyme Inhibition and in vitro Cytotoxicity
Gagan Tiwana, Ian Edwin Cock, Matthew James Cheesman
Volume 16, Issue 4 · pp. 163–170 · 2026
Background: The increasing prevalence of β-lactamase-mediated antimicrobial resistance has substantially reduced the effectiveness of β-lactam antibiotics, highlighting the need to identify novel β-lactamase inhibitors. Medicinal plants are rich sources of structurally diverse…
DOI: 10.5530/pc.2026.4.21
Original Article
The Interactive Antimicrobial Activity of Terminalia ferdinandiana Exell. Extracts and Conventional Antibiotics against Bacterial Triggers of Some Autoimmune Diseases
Xiayi Guo, Junyu Liu, Ian Edwin Cock
Volume 16, Issue 4 · pp. 171–185 · 2026
Autoimmune inflammatory diseases are debilitating conditions for which limited safe and effective therapeutic options exist. A re-examination of traditional medicines may highlight leads for therapies against those diseases. Terminalia ferdinandiana has strong antibacterial…
DOI: 10.5530/pc.2026.4.22
Original Article
Advancing Pharmacognostic Assessment through Perfused 3D Tumor Co-Cultures: Critical Insights into Drug Transport, Immune Modulation, and Resistance
Victor Akpe, Temiyefunolu Akuchukwu Ngwu, Ian Edwin Cock
Volume 16, Issue 4 · pp. 186–195 · 2026
Background: Perfused Three-dimensional (3D) tumor co-culture systems are increasingly recognized as valuable platforms for pharmacognostic assessment, providing microenvironmental fidelity that enhances evaluation of natural product bioactivity, drug transport, and resistance…
DOI: 10.5530/pc.2026.4.23
The Janus Corner
been and continues to evolve within our times. Pterostilbene, Found in Blueberries Supress Lipid Accumulation in Muscle Cells and Stimulate Fat Metabolism
Ian Edwin Cock
Volume 16, Issue 4 · pp. 196–196 · 2026
The accumulation of lipids in skeletal muscle as the result of high fat diets, physical inactivity and during aging can result in metabolic dysfunction. This may result interfere with the ability of the cells to efficiently use glucose and fatty acids for energy metabolism,…
DOI: 10.5530/pc.2026.4.24
Original Article
Bidens biternata (Lour.) Merr. and Sherff Whole Plant Extract Fractions Inhibit the Growth of a Panel of Pathogenic Bacteria
Xu You Duan, Ian Edwin Cock
Volume 16, Issue 2 · pp. 76–84 · 2026
Introduction: Bidens biternata (Lour.) Merr. and Sherff is used in several medicinal systems (including traditional Chinese medicine) for multiple purposes, including to treat bacterial infections. Despite this, B. biternata extracts, fractions and isolated compounds have not…
DOI: 10.5530/pc.2026.2.8
Original Article
Antibacterial Efficacy and Cytotoxicity of Terminalia avicennioides Guill. and Perr. Stem Bark Extract Against Resistant Pathogens
Temiyefunolu A. Ngwu, Oluwaseun. O Olasunkanmi, Victor Akpe, Ian Edwin Cock
Volume 16, Issue 2 · pp. 85–94 · 2026
Background: The global rise of antimicrobial resistance (AMR) has created an urgent need for alternative therapeutic agents, particularly from medicinal plants used in traditional medicine. Terminalia avicennioides Guill. and Perr. is widely used in West Africa for treating…
DOI: 10.5530/pc.2026.2.9
Original Article
Syzygium australe (J.C.Wendl. ex Link) B.Hyland and Syzygium luehmannii (F.Meell.) L.A.S. Johnson Extracts Inhibit Methicillin-Resistant Staphylococcus aureus and ESBL Escherichia coli and Klebsiella pneumoniae
Marie-Elisabeth Cordon, Ian Edwin Cock
Volume 16, Issue 2 · pp. 95–108 · 2026
Background: Recent increases in antibiotic-resistant bacteria infections has focussed researcher’s attention on alternative therapies, including traditional plant-based medicines. The rapid development β-lactam resistant bacterial strains with resistance to later generation…
DOI: 10.5530/pc.2026.2.10
The Janus Corner
Think Twice When Using Melatonin to Aid Sleep: New Research Links its Use to Heart Failure Risk
Ian E Cock
Volume 16, Issue 2 · pp. 109–109 · 2026
Melatonin is commonly used to assist in with sleep disorders and its use is generally regarded as harmless. However, a recent report by the American Heart Association1 has highlighted previously unreported risks to cardiac function with its use. Indeed, patients that used…
DOI: 10.5530/pc.2026.2.11
Original Article
Lack of Antibacterial Activity in the Ayurvedic Plants Aconitum heterophyllum, Tephrosia purpurea, Tinospora cordifolia and Swertia chirayita
Gagan Tiwana, Ian Edwin Cock, Matthew James Cheesman
Volume 16, Issue 1 · pp. 14–38 · 2026
Background:The global rise of antimicrobial resistance (AMR) has intensified the search for alternative therapeutic agents derived from natural sources. This study investigated the antibacterial potential of four Ayurvedic medicinal plants Aconitum heterophyllum, Tephrosia…
DOI: 10.5530/pc.2026.1.3
Original Article
Ocimum tenuiflorum Linn. and Solanum nigrum Linn. Plant Extracts Possess Little to no Activity against Antibiotic Resistant and Susceptible Bacteria and are Non-toxic in vitro
Gagan Tiwana, Ian E. Cock, Matthew J. Cheesman
Volume 16, Issue 1 · pp. 39–60 · 2026
Background:Ayurvedic medicines have been used for thousands of years. Bacterial infections comprise the conditions that are treated by the plant-based medicinal therapy. Due to the increasing levels of bacterial resistance to antibiotics, new therapies are desperately needed,…
DOI: 10.5530/pc.2026.1.4
Review Article
Review of the Pharmacological Properties and Phytochemical Profile of Ptaeroxylon obliquum (Thunb.) Radlk
Jinwoo Kim, Ian Edwin Cock, Matthew James Cheesman
Volume 15, Issue 4 · pp. 153–162 · 2025
Introduction: Ptaeroxylon obliquum (Thunb.) Radlk. That is a medium tree native to South Africa. It has been traditionally used for centuries to treat a wide range of disorders. Objectives: This study reviews the pharmacological profile of South African Ptaeroxylon obliquum…
DOI: 10.5530/pc.2025.4.20
Original Article
Extracts Prepared from Selected High Antioxidant Australian Plants Inhibit Proliferation of HeLa and Caco-2 Carcinoma Cells
Joseph Shalom, Ian Edwin Cock
Volume 15, Issue 4 · pp. 163–171 · 2025
Background: High antioxidant foods have been linked to multiple therapeutic properties, including the anticancer and anti-inflammatory properties. Despite this, the anticancer activities of many Australian native plants with high antioxidant capacities are yet to be adequately…
DOI: 10.5530/pc.2025.4.21
Original Article
Tasmannia lanceolata (Poir.) A.C.Sm. Pepperberry Extracts Inhibit the Growth of the Pharyngitis Causing Pathogen Streptococcus pyogenes
Veronica Winnett, Ian Edwin Cock
Volume 15, Issue 4 · pp. 172–178 · 2025
Introduction: Streptococcus pyogenes is a gram positive pathogenic bacterium which causes a variety of diseases including streptococcal pharyngitis, impetigo and rheumatic heart disease, depending on which tissue it infects. Tasmannia lanceolata (Poir.) A.C.Sm. pepperberries…
DOI: 10.5530/pc.2025.4.22
Original Article
Tasmannia insipida R.Br. Ex DC. Leaf Extracts Inhibit the Growth of the Acne Vulgaris Causing Bacterium Cutibacterium acnes
Ian Edwin Cock
Volume 15, Issue 4 · pp. 179–185 · 2025
Introduction: Acne vulgaris is a skin conditions that affects most adolescents and also afflicts some adults. Medicinal plant extracts may provide leads for the development of new topical and/ or oral therapies for acnes vulgaris, yet many traditional medicine plants are yet to…
DOI: 10.5530/pc.2025.4.23
The Janus Corner
Medical Cannabis sativa L. Use Improves Quality of Life for People with Chronic Illnesses
Ian E Cock
Volume 15, Issue 4 · pp. 186–187 · 2025
The use of medicinal cannabis in patients with chronic illnesses has risen significantly in recent years globally, particularly in people suffering from chronic illnesses. A recent study Published in PLOS One examined the long-term effects of cannabis use on health-related…
DOI: 10.5530/pc.2025.4.24
