Article · Volume 1, Issue 3 · pp. 105–106

Pharmacological Studies on ‘Clove’ Eugenia caryophyllata

I.A. Al-Mofleh¹, A.A. Alhaider¹, J.S. Mossa², M.O. Al-Sohaibani³, S. Qureshi², S. Rafatullah²

¹Gastroenterology Unit (59), College of Medicine & KKUH, King Saud University, P.O. Box 2925, Riyadh-11461, Saudi Arabia.
²Department of Pharmacognosy and Pharmacology, Medicinal, Aromatic and Poisoning Plants Research Center, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh-11451, Saudi Arabia.
³Department of Pathology (32), College of Medicine & KKUH, King Saud University, P.O. Box 2925, Riyadh-11461, Saudi Arabia.

Abstract

An aqueous suspension of clove, Eugenia caryophyllata (Spreng.) (Myrtaceae) was tested for its ability to inhibit basal gastric secretion and to protect gastric mucosa against the injuries caused by pyloric ligation, indomethacin and cytodestructive agents (80% ethanol, 0.2 M NaOH and 25% NaCl) in rats. The suspension in doses of 250 and 500 mg/kg body weight had a significant antiulcerogenic activity on the models used. Besides, ethanol-induced depleted non-protein sulfhydryl (NP-SH) and gastric wall mucus contents were replenished by pretreatment with clove suspension. No significant histopathological changes are noted. In acute, chronic and genotoxicity tests clove suspension showed a large margin of safety in the animals and did not induce any significant changes in the micronucleated polychromatic erythrocytes (PCE) and the ratio of PCE and normochromatic erythrocytes (NCE) at both doses used, as compared to control group, suggesting lack of any significant clastogenic and/or cytotoxic potentials.

Keywords: Eugenia caryophyllata; anti-ulcerogenic; Genotoxicity; micronucleated polychromatic erythrocytes; clastogenic; cytotoxic

The full text of this article is available as a PDF. Open the PDF.