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Recent articles
15 articles · what your feed deliversReview Article
Anchusa italica Retz.: A Review of Chemical Composition, Pharmacological Effects, and Network Analysis
Chen Liang, Xu Xiao-Qin, Guo Wen-Hui, Mai Di-Na
Volume 22, Issue 4 · pp. 1231–1245 · 2026
Anchusa italica Retz., a botanical drug belonging to the Anchusa genus of the Boraginaceae family, is a traditional Chinese botanical drug and medicine widely used in Uygur medicine for treating palpitations, insomnia, neurasthenia, hypertension, and other disorders. Recent…
Original Research Article
Anti-arthritic Activity of Citral Against Complete Freund’s Adjuvant-induced Arthritis in Rats Through NF-κB Signaling Pathway
Fan-Bin Kong, Jian-Hua Liu
Volume 22, Issue 4 · pp. 1246–1256 · 2026
Background: Citral is a bioactive compound found in lemongrass oil. It functions as an antioxidant and possesses anti-inflammatory qualities. Objectives: The purpose of this study was to assess the anti-arthritic benefits of citral using a rat model with an adjuvant arthritis…
Original Research Article
Hepatoprotective Activity of Ligustilide Against Acetaminophen-induced Acute Liver Toxicity in Rats via Inhibiting Oxidative Stress and Inflammatory Responses
Xin Pang, Yuan Tian, Shasha Du, Jinyu Liu, Feimei Wang
Volume 22, Issue 4 · pp. 1257–1268 · 2026
Background: Drug-induced liver toxicity is a major clinical challenge, being the primary cause of abrupt liver failure. This condition is intensified by an older population that consumes more drugs and the increasing hazards associated with unknown drug consumption. Objectives:…
Original Research Article
Exploring the Mechanism of Baicalein in Treating Oral Lichen Planus: A Network Pharmacology and Single-cell RNA Sequencing Analysis
Dan Zhou, Zehan Zhang, Zhilin Chen, Jianxing Zhang, Chao Pei
Volume 22, Issue 4 · pp. 1269–1280 · 2026
Background: Oral lichen planus (OLP) is a prevalent chronic inflammatory oral mucosal disease with an uncertain pathogenesis and limited treatment options. Objectives: This study aimed to systematically explore the underlying therapeutic mechanisms of baicalein in the treatment…
Original Research Article
Polydopamine Nanoparticle-encapsulated Psoralen Promotes Motor Function Recovery from Spinal Cord Compression Through Regulating Phosphatidylinositol 3-kinase/Protein Kinase B Signaling Through miR-140-5p
Jian Deng, Zongyao Duan, Hao Deng, Lu Ye
Volume 22, Issue 4 · pp. 1281–1290 · 2026
Background: Psoralen is a biomaterial that promotes bone growth and repair and has been widely used in clinical orthopedic surgeries. Objectives: This study aims to explore the role and mechanism of polydopamine nanoparticle-encapsulated psoralen (PSO/PDA NPs) in the recovery of…
Original Research Article
Research on Mechanism of Microenvironment of Myeloma Being Restored by Allicin Regulating the Activity of Hedgehog Pathway Through miR-29b
Yanli Wang, Fen Xie, Ying Cai, Ping Xiang
Volume 22, Issue 4 · pp. 1291–1300 · 2026
Background: The proliferation of myeloma cells could be affected partly by the interaction between microRNA-29b (miR-29b) and Hedgehog. Objectives: The research on the mechanism of microenvironment of myeloma being restored by allicin, regulating the activity of Hedgehog pathway…
Original Research Article
Osteogenic and Angiogenic Differentiation of Bone Mesenchymal Stem Cells Induced by Different Concentrations of Icariin
Xiang Zhu, Shuang Zheng, Dengke Li, Ying Yang, Jinrong Zhao
Volume 22, Issue 4 · pp. 1301–1309 · 2026
Background: Bone defects resulting from trauma or lesions are common orthopedic conditions that challenge bone regeneration. Bone mesenchymal stem cells (BMSCs) have garnered attention due to their osteogenic potential. Icariin has shown promise in promoting osteogenic and…
Original Research Article
Liposome Nanoparticles Encapsulating Dehydrocameline Inhibit Cyclooxygenase-2 Expression and Reduce Inflammatory Response in Gastric Cancer Mice
Chengcheng Xu, Shaoqi Chen, Yaning Bo, Qi Gui
Volume 22, Issue 4 · pp. 1310–1320 · 2026
Background: Dehydrokoline has a wide range of pharmacological activities and exhibits anti-tumor potential effects in a variety of cancer types. Whether it plays a role in gastric cancer remains unclear. Objectives: This study aims to explore the mechanism by which liposome…
Original Research Article
Curcumin Loaded with Ferric Oxide Nanoparticles Reduces Hypoxic Injury in Myocardial Infarction by Regulating miR-208 and Activating SIRT1 Signaling Pathway
Dandan Wei, Lei Zhao
Volume 22, Issue 4 · pp. 1321–1333 · 2026
Background: Curcumin has antioxidant and anti-myocardial ischemic effects, but its low water solubility and bioavailability limit clinical application. Objectives: This study aims to explore whether curcumin-loaded ferric oxide nanoparticles alleviate hypoxic injury in…
Original Research Article
Efficacy and Safety Study of Linagliptin in Brittle Diabetes Mellitus Combined with Early Diabetic Nephropathy Treated with Dendrobium Polysaccharide Extracts
Xiaoling Li, Liye Hu
Volume 22, Issue 4 · pp. 1334–1344 · 2026
Objectives: Linagliptin reduces blood glucose levels, but its efficacy in brittle diabetes mellitus with early diabetic nephropathy (BDM-EDN) remains unclear. Therefore, this study investigated the efficacy and safety of linagliptin in BDM-EDN treated with Dendrobium…
Original Research Article
Extracts from Tenebrio molitor Larvae and Protaetia brevitarsis Larvae Reduced Cadmium-induced Ferroptosis and Cytotoxicity in Hep3B Cells
Hyomin Lim, Yookyung Kim, Woo-Jae Park
Volume 22, Issue 4 · pp. 1345–1355 · 2026
Background: Cadmium is a hepatotoxic heavy metal. Cadmium is known to induce ceramide generation and ferroptosis. Edible insects have recently been touted as a potential functional food. Various studies are being conducted in this regard. Objectives: This study was designed to…
Original Research Article
Protective Effects of Althaea officinalis L. Against Cyclophosphamide-induced Immunosuppression and Bone Marrow/Spleen Injuries in Rats
Min Sun, Shengju Wu, Guozhen Yi, Li Yu
Volume 22, Issue 4 · pp. 1356–1370 · 2026
Background: Chemotherapy targets rapidly dividing cells, impacting HSCs and hematopoiesis. Objectives: We evaluated the protective impacts of Althaea officinalis L. extract (AOE) against cyclophosphamide (CP)- related immunosuppression and damage to the spleen and bone marrow…
Original Research Article
Mesoporous Silica-mediated Chonglou Saponin Inhibits Esophageal Cancer Cells Growth Through Regulating Fibroblast Growth Factor 19/Fibroblast Growth Factor 19 Signaling Axis
Yuduo Wang, Xuezhen Ma
Volume 22, Issue 4 · pp. 1371–1380 · 2026
Background: Chonglou saponin has been found to have certain tumor suppressor effects in a variety of cancers. However, Chonglou saponin has certain limitations and side effects in clinical application. Therefore, exploring new therapeutic strategies and mechanisms of action of…
Original Research Article
Impact of Resveratrol on Arrhythmias in Chronic Ischemic Heart Failure: Insights from Biochemical, Molecular, and Histopathological Studies in a Rat Model
He Jing, Fuxian Wei, Yan Wang
Volume 22, Issue 4 · pp. 1381–1390 · 2026
Background: Ventricular arrhythmias (VAs) frequently arise as complications in chronic ischemic heart failure (CIHF). Objectives: We evaluated the effectiveness of resveratrol (RES) in a CIHF-induced rat model of VAs and explored the underlying mechanisms. Materials and Methods:…
Original Research Article
Impact of Apricot Kernel Oil on Reproductive Toxicity in Mice: Insights into Mitochondrial Apoptotic Pathways During Early Pregnancy
Xiaoyan Wang, Zheng Liu
Volume 22, Issue 4 · pp. 1391–1401 · 2026
Background: When the endometrium matures in step with the required morphological changes, blastocyst implantation occurs more effectively. Objectives: The present study aimed to examine the reproductive toxicity of apricot kernel oil (AK oil) by using an animal model of early…