Volume 22, Issue 4

Chen Liang, Xu Xiao-Qin, Guo Wen-Hui, Mai Di-Na

pp. 1231–1245 · DOI: 10.1177/09731296261461015 · 2026

Anchusa italica Retz., a botanical drug belonging to the Anchusa genus of the Boraginaceae family, is a traditional Chinese botanical drug and medicine widely used in Uygur medicine for treating palpitations, insomnia, n…

Fan-Bin Kong, Jian-Hua Liu

pp. 1246–1256 · DOI: 10.1177/09731296251326642 · 2026

Background: Citral is a bioactive compound found in lemongrass oil. It functions as an antioxidant and possesses anti-inflammatory qualities. Objectives: The purpose of this study was to assess the anti-arthritic benefit…

Xin Pang, Yuan Tian, Shasha Du, Jinyu Liu, Feimei Wang

pp. 1257–1268 · DOI: 10.1177/09731296251360570 · 2026

Background: Drug-induced liver toxicity is a major clinical challenge, being the primary cause of abrupt liver failure. This condition is intensified by an older population that consumes more drugs and the increasing haz…

Dan Zhou, Zehan Zhang, Zhilin Chen, Jianxing Zhang, Chao Pei

pp. 1269–1280 · DOI: 10.1177/09731296251387401 · 2026

Background: Oral lichen planus (OLP) is a prevalent chronic inflammatory oral mucosal disease with an uncertain pathogenesis and limited treatment options. Objectives: This study aimed to systematically explore the under…

Jian Deng, Zongyao Duan, Hao Deng, Lu Ye

pp. 1281–1290 · DOI: 10.1177/09731296251385791 · 2026

Background: Psoralen is a biomaterial that promotes bone growth and repair and has been widely used in clinical orthopedic surgeries. Objectives: This study aims to explore the role and mechanism of polydopamine nanopart…

Yanli Wang, Fen Xie, Ying Cai, Ping Xiang

pp. 1291–1300 · DOI: 10.1177/09731296251388240 · 2026

Background: The proliferation of myeloma cells could be affected partly by the interaction between microRNA-29b (miR-29b) and Hedgehog. Objectives: The research on the mechanism of microenvironment of myeloma being resto…

Xiang Zhu, Shuang Zheng, Dengke Li, Ying Yang, Jinrong Zhao

pp. 1301–1309 · DOI: 10.1177/09731296251388230 · 2026

Background: Bone defects resulting from trauma or lesions are common orthopedic conditions that challenge bone regeneration. Bone mesenchymal stem cells (BMSCs) have garnered attention due to their osteogenic potential. …

Chengcheng Xu, Shaoqi Chen, Yaning Bo, Qi Gui

pp. 1310–1320 · DOI: 10.1177/09731296251388231 · 2026

Background: Dehydrokoline has a wide range of pharmacological activities and exhibits anti-tumor potential effects in a variety of cancer types. Whether it plays a role in gastric cancer remains unclear. Objectives: This…

Dandan Wei, Lei Zhao

pp. 1321–1333 · DOI: 10.1177/09731296251388232 · 2026

Background: Curcumin has antioxidant and anti-myocardial ischemic effects, but its low water solubility and bioavailability limit clinical application. Objectives: This study aims to explore whether curcumin-loaded ferri…

Xiaoling Li, Liye Hu

pp. 1334–1344 · DOI: 10.1177/09731296251388229 · 2026

Objectives: Linagliptin reduces blood glucose levels, but its efficacy in brittle diabetes mellitus with early diabetic nephropathy (BDM-EDN) remains unclear. Therefore, this study investigated the efficacy and safety of…

Hyomin Lim, Yookyung Kim, Woo-Jae Park

pp. 1345–1355 · DOI: 10.1177/09731296261444147 · 2026

Background: Cadmium is a hepatotoxic heavy metal. Cadmium is known to induce ceramide generation and ferroptosis. Edible insects have recently been touted as a potential functional food. Various studies are being conduct…

Min Sun, Shengju Wu, Guozhen Yi, Li Yu

pp. 1356–1370 · DOI: 10.1177/09731296251396325 · 2026

Background: Chemotherapy targets rapidly dividing cells, impacting HSCs and hematopoiesis. Objectives: We evaluated the protective impacts of Althaea officinalis L. extract (AOE) against cyclophosphamide (CP)- related im…

Yuduo Wang, Xuezhen Ma

pp. 1371–1380 · DOI: 10.1177/09731296251396323 · 2026

Background: Chonglou saponin has been found to have certain tumor suppressor effects in a variety of cancers. However, Chonglou saponin has certain limitations and side effects in clinical application. Therefore, explori…

He Jing, Fuxian Wei, Yan Wang

pp. 1381–1390 · DOI: 10.1177/09731296251400033 · 2026

Background: Ventricular arrhythmias (VAs) frequently arise as complications in chronic ischemic heart failure (CIHF). Objectives: We evaluated the effectiveness of resveratrol (RES) in a CIHF-induced rat model of VAs and…

Xiaoyan Wang, Zheng Liu

pp. 1391–1401 · DOI: 10.1177/09731296251403326 · 2026

Background: When the endometrium matures in step with the required morphological changes, blastocyst implantation occurs more effectively. Objectives: The present study aimed to examine the reproductive toxicity of apric…

Bo Xiong, Jianju Zhou, Hang Li, Yuanchao Wen

pp. 1402–1412 · DOI: 10.1177/09731296251404218 · 2026

Background: Tanshinone (TSL) is a good traditional Chinese medicine with a wide range of applications. Whether it plays a role in ischemic cerebral infarction is unclear. Objectives: This study aims to explore the mechan…

Yujing Meng, Zhenyu Zhao

pp. 1413–1423 · DOI: 10.1177/09731296251385371 · 2026

Background: Prostate cancer is one of the most common malignancies in men, and immune escape is one of the major challenges in development and treatment. In a hypoxic environment, tumor cells may reduce or stop expressin…

Suhas Tambe, P. Sivakami Sundari, Geetha Kannoth Mukundan

pp. 1424–1437 · DOI: 10.1177/09731296251411620 · 2026

Background and Objectives: Nutraceuticals are products being used as food and medicines for the treatment of several chronic diseases. The herbal nutraceuticals are gaining importance because of a wide variety of biologi…

Pengcheng Shen, Ying Lan, Zhe Bai

pp. 1438–1448 · DOI: 10.1177/09731296261417098 · 2026

Background: Sepsis-associated acute lung injury (SALI) is characterized by an uncontrolled inflammatory response and cell apoptosis, with macrophage apoptosis playing a key role in alveolar barrier disruption. Spermidine…

Xi Jiang, Yubo Yang, Hanqing Zhang, Huidan Dai, Yuyang Huang, Xuefeng Yu

pp. 1449–1456 · DOI: 10.1177/09731296261427823 · 2026

Background: Diabetic foot ulcer, a severe complication occurring in diabetic patients, lacks effective remedies at present. Objectives: The objective of this research is to investigate the impacts of exogenous irisin on …