Volume 22, Issue 4

Original Research Article(continued)

1. Article

   Nutraceutical Iridoid Glycoside Monotropein Induces Apoptosis and Suppresses PI3K/Akt/mTOR Signaling in Breast Cancer Cells: An In Vitro Evaluation

   Jin Che, Xiaoxu Han, Xiaomin Li

   pp. 1672–1681 · DOI: 10.1177/09731296261471009 · 2026

   Background: The rising global burden of breast cancer, marked by increasing incidence and mortality rates, has intensified the pursuit of anti-cancer agents that are both effective and mechanistically targeted while mini…

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2. Article

   Paeoniflorin Increases Prostaglandinendoperoxide Synthase 2 to Reduce Inflammation and Inhibit Colon Cancer Tumor Growth

   Yi Zhang, Cuixia Liu, Yiwei Fu, Ni Liu, Wang Zhou

   pp. 1682–1689 · DOI: 10.1177/09731296261466775 · 2026

   Background: Paeoniflorin, a principal bioactive component of Paeoniae Alba, inhibits liver, gastric, and lung cancers, but its precise role in colon cancer remains unclear. Objectives: To explore the mechanism by which p…

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3. Article

   Panax ginseng Extract Improves Fibromyalgialike Symptoms in Mice: Involvement of Hippocampal BDNF–CREB Signaling

   Hak-Jae Kim, Ji-an Lee, Shinwoo Kang, Jun-Tack Kwon, Jin Kim, Myeounghoon Cha, Young Hyun Jung, Jeong Beom Lee

   pp. 1690–1699 · DOI: 10.1177/09731296261474292 · 2026

   Background: Fibromyalgia affects 2%–4% of the population with limited treatment options. Panax ginseng C. A. Meyer has been used traditionally for stress-related disorders, but the mechanisms are not well understood. Obj…

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