A Study on the Beneficial Effect of Mangiferin on Isoproterenol Induced Mycocardial Infarction Rat Model

Abstract

Over the past last decades there exist a relationship between diet and the development of major chronic diseases such as chronic heart diseases, hypertension and cancer. Mangiferin, the important phytochemical constituent of Mangifera indica L. has been used in the treatment of various human ailments. In this article an attempt has been made to evaluate the beneficial effect of mangiferin on isoproterenol induced myocardial infarction in rats. The ratio of heart weight to body weight was monitored as an index to study the cardioprotective property in the animal model. The following hematological parameters, RBC counts, haemoglobin amount, packed cell volume, total WBCs, neutrophil, eosnophil counts and platelet count, fibrinogen content, ESR, the percentage of lymphocytes, eosinophil counts, clotting time, bleeding time and prothrombin time were studied. The pretreatment with mangiferin prevented the alterations induced by isoproterenol and retained the hematological changes to near normal.

Keywords: Myocardial infarction; Mangiferin; Hematological alterations; cardioprotective