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PM · Lens · Neuroprotective effects of 4,5-dimethoxypyrocatechol isolated from Cynanchum paniculatum on HT22 cells

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Article · Volume 10, Issue 38 · pp. 161–164

Neuroprotective effects of 4,5-dimethoxypyrocatechol isolated from Cynanchum paniculatum on HT22 cells

Jin Bae Weon2, Bohyoung Lee2, Bo-Ra Yun2, Jiwoo Lee2, Choong Je Ma2,3

  1. 1Department of Medical Biomaterials Engineering, College of Biomedical Science, Kangwon National University.
  2. 2Research Institute of Biotechnology, Kangwon National University, Chuncheon, Korea.

Abstract

Background: Cynanchum paniculatum, belongs to the family Asclepiadaceae and is used to treat various diseases, such as invigorate blood, alleviate edema and to relieve pain and toxicity for a long time.Materials and Methods: 4,5-Dimethoxypyrocatechol was isolated from the 80% methanol extract of C. paniculatum and its neuroprotective effect was evaluated by MTT assay.Results: 4,5-Dimethoxypyrocatechol had neuroprotective effect on the glutamate-induced cellular oxidative death in HT22 cells.Conclusion: Furthermore, we found that reactive oxygen species (ROS) accumulation and calcium concentration by oxidative stress were reduced by 4,5-dimethoxypyrocatechol in HT22 cells.

Keywords: Cynanchum paniculatum; 4; 5-dimethoxypyrocatechol; HT22 cells; neuroprotective effect

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