Article · Volume 10, Issue 38S · pp. 334–341
Cytotoxic neviotane triterpene‑type from the red sea sponge Siphonochalina siphonella
Rihab F. Angawi2, Esraa Saqer2, Ahmed Abdel‑Lateff3,4, Farid A. Badria6, Seif‑Eldin N. Ayyad2,5
- 1Department of Chemistry.
- 2Department of Natural Products and Alternative Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
- 3Department of Pharmacognosy, Minia University, Minia 61519.
- 4Department of Chemistry, Dammietta University, New Dammietta.
- 5Department of Pharmacognosy, Mansoura University, Mansoura 35516, Egypt.
Abstract
Background: Siphonochalina siphonella is a marine sponge collected from saudi Red Sea water and scare study from this region.Objective: To isolate the anticancer triterpenes with potent cytotoxicity from marine sponge, Siphonochalina siphonella and state the mode of action in cancer cell lines.Materials and Methods: The sponge material was collected, extracted with organic solvent, and fractionated on different adsorbents. The structure of the pure metabolites were elucidated employing different spectroscopic techniques including 1D (1H and 13C) and 2D (COSY, HMQC and HMBC) NMR, and MS spectroscopy.Results: A new Neviotine‑C (1) was obtained, along with four known metabolites (2‑5). All compounds, except 5, were tested towards MCF‑7, PC‑3 and A549 and showed effects with IC50 in range 7.9‑87 µM, whilst, 3 showed potent anti‑proliferative activity against PC‑3 and A549 with IC50 = 7.9 ± 0.120 and 8.9 ± 0.010 µM, respectively.Conclusion: Compounds (1‑4) showed significant cytotoxic activities, while 3 showed potent effect. The antiproliferative of 3 was attributed to significant S‑phase cell cycle arrest.
Keywords: Marine; sponge; Siphonochalina; triterpenes and anticancer A B S T R A C T
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