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PM · Lens · Inhibitory potential of some Romanian medicinal plants against enzymes linked to neurodegenerative diseases and their antioxidant activity

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Article · Volume 11, Issue 42S · pp. 110–116

Inhibitory potential of some Romanian medicinal plants against enzymes linked to neurodegenerative diseases and their antioxidant activity

Gabriela Paun2, Elena Neagu2, Camelia Albu2, Gabriel Lucian Radu2,3

  1. 1Centre of Bioanalysis, National Institute for Research‑Development of Biological Sciences, Centre of Bioanalysis, 060031 Bucharest.
  2. 2Department of Analytical Chemistry, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, 060042 Bucharest, Romania.

Abstract

Context: Eryngium planum, Geum urbanum and Cnicus benedictus plants are an endemic botanical from the Romanian used in folk medicine.Objective: The extracts from three Romanian medicinal plants were investigated for their possible neuroprotective potential.Materials and Methods: Within this study, in vitro neuroprotective activity of the extracts of E. planum, G. urbanum, and C. benedictus plants were investigated via inhibition of acetylcholinesterase (AChE) and tyrosinase (TYR). Total content of phenolics, flavonoids, and proanthocyanidins, high‑performance liquid chromatography profile of the main phenolic compounds and antioxidant activity were also determined.Results: Among the tested extracts, the best inhibition of AChE (88.76 ± 5.2%) and TYR (88.5 ± 5.2%) was caused by C. benedictus ethanol (EtOH) extract. The G. urbanum extracts exerted remarkable scavenging effect against 2,2‑diphenyl‑1‑picrylhydrazyl (IC50, 7.8 ± 0.5 µg/mL aqueous extract, and IC50, 1.3 ± 0.1 µg/mL EtOH extract, respectively) and reducing power, whereas the EtOH extract of C. benedictus showed high scavenging activity (IC50, 0.609 ± 0.04 mg/mL), also.Conclusion: According to our knowledge, this is the first study that demonstrates in vitro neuroprotective effects of E. planum, G. urbanum and C. benedictus.

Keywords: Antioxidant; Cnicus benedictus; enzyme inhibition; Eryngium planum; Geum urbanum; neurodegenerative diseases A B S T R A C T

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