Article · Volume 11, Issue 44S2 · pp. 496–500
Modulatory Role of Shorea robusta Bark on Glucose-metabolizing Enzymes in Diethylnitrosamine Induced Hepatocellular Carcinoma in Rats
A. Kalaiselvan1, T. Anand2, K. Gokulakrishnan3, M. C. Kamaraj3, S. Velavan3
- 1Centre for Research and Development, PRIST University, Thanjavur, Tamil Nadu, India.
- 2Department of Chemistry, PRIST University, Thanjavur, Tamil Nadu, India.
- 3Department of Biochemistry, Marudupandiyar College, Thanjavur, Tamil Nadu, India.
Abstract
Introduction: The modulations of glucose‑metabolizing enzyme activities play a vital rolein the depletion of energy metabolism and leads to inhibition of cancer growth.Objective: To find the effect of shorearobusta bark extract on glucose-metbolizing enzymes in diethylnitrosamine (DEN) induced hepatocellular carcinoma rats.Materials and Methods: Biochemical evaluation of glucose metabolizing enzyme were done in before and after shorearobusta bark extract (500mg/kg) treatment in DEN induced rats.Results: A significant increasein the activities of the key glycolytic enzymes viz., hexokinase and phosphoglucoisomerase, with a significant decrease in the gluconeogenic enzymes glucose‑6‑phosphatase and fructose‑1,6‑bisphosphatasewere observed in HCC bearing rats, when compared with the control. Administration of shorearobusta extract caused a significant decrease in theactivities of glycolytic enzymes and an increase in the gluconeogenic enzymes activities to near normal values.Conclusion: The current findings suggest that the S. robusta extract has a definite modulating role on the key enzymes ofglucose‑metabolism in HCC. The modulatory effect may be due to the phytoactive constituents present in the extract of S. robusta.
Keywords: Diethylnitrosamine; glucose‑metabolizing enzymes; hepatocellular carcinoma; Shorea robusta
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